{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:38:50Z","timestamp":1789609130889,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T00:00:00Z","timestamp":1463961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Although guidelines recommend normalization of platelet counts as an appropriate endpoint for treatment in high\u2010risk essential thrombocythemia (<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>), retrospective studies could not prove a correlation of diagnostic platelet counts with an increased thrombotic rate. There is, however, an increasing evidence that leukocytosis is an important risk factor for arterial thrombosis in myeloproliferative neoplasms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study considers the Austrian cohort of a European registry regarding the platelet\u2010lowering therapeutic anagrelide. Influence of platelet and white blood cell (<jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>) counts on thrombotic risk was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using the calculated cutoffs of 574.5 G\/L for platelets and 8.48 G\/L for <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content> counts, respectively, the Cox regression analysis revealed a clear influence of elevated platelets (<jats:italic>P<\/jats:italic> = 0.008) and <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content> counts (<jats:italic>P<\/jats:italic> = 0.011) on the occurrence of major thrombotic events. The time to a major thrombotic event was shortest (<jats:italic>P<\/jats:italic> &lt; 0.001) and the frequency related to 100 patient\u2010years was highest (<jats:italic>P<\/jats:italic> = &lt;0.001) when both platelet and <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content> counts ranged above the calculated cutoffs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data add evidence to the impact of platelet and <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content> counts on thrombosis in <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>. We suspect a particular interaction between platelets and <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content> which might be based on a biological interplay depending on particular cell counts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12759","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T19:17:09Z","timestamp":1459624629000},"page":"511-516","source":"Crossref","is-referenced-by-count":39,"title":["Influence of platelet and white blood cell counts on major thrombosis \u2013 analysis from a patient registry in essential thrombocythemia"],"prefix":"10.1111","volume":"97","author":[{"given":"Veronika","family":"Buxhofer\u2010Ausch","sequence":"first","affiliation":[{"name":"Division of Hematology and Blood Coagulation Department of Internal Medicine I Medical University of Vienna Vienna Austria"},{"name":"Department of Internal Medicine I Elisabethinen Hospital Linz Linz 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