{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:56:18Z","timestamp":1769756178682,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T00:00:00Z","timestamp":1465430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NT13492"],"award-info":[{"award-number":["NT13492"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Monoclonal gammopathy of undetermined significance (<jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content>) is a benign condition with an approximate 1% annual risk of symptomatic plasma cell disorder development, mostly to multiple myeloma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>). We performed genomewide screening of copy\u2010number alterations (<jats:styled-content style=\"fixed-case\">CNA<\/jats:styled-content>s) in 90 <jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content> and 33 <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> patients using high\u2010density <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> microarrays. We identified <jats:styled-content style=\"fixed-case\">CNA<\/jats:styled-content>s in a smaller proportion of <jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content> (65.6%) than in <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> (100.0%, <jats:italic>P<\/jats:italic> = 1.31 \u00d7 10<jats:sup>\u22125<\/jats:sup>) and showed median number of <jats:styled-content style=\"fixed-case\">CNA<\/jats:styled-content>s is lower in <jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content> (3, range 0\u201322) than in <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> (13, range 4\u201338, <jats:italic>P<\/jats:italic> = 1.82 \u00d7 10<jats:sup>\u221210<\/jats:sup>). In the <jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content> cohort, the most frequent losses were located at 1p (5.6%), 6q (6.7%), 13q (30.0%), 14q (14.4%), 16q (8.9%), 21q (5.6%), and gains at 1q (23.3%), 2p (6.7%), 6p (13.3%), and Xq (7.8%). Hyperdiploidy was detected in 38.9% of <jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content> cases, and the most frequent whole chromosome gains were 3 (25.6%), 5 (23.3%), 9 (37.8%), 15 (23.3%), and 19 (32.2%). We also identified <jats:styled-content style=\"fixed-case\">CNA<\/jats:styled-content>s such as 1p, 6q, 8p, 12p, 13q, 16q losses, 1q gain and hypodiploidy, which are potentially associated with an adverse prognosis in <jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content>. In summary, we showed that <jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content> is similar to <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> in that it is a genetically heterogeneous disorder, but overall cytogenetic instability is lower than in <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>, which confirms that genetic abnormalities play important role in monoclonal gammopathies.<\/jats:p>","DOI":"10.1111\/ejh.12774","type":"journal-article","created":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T11:28:20Z","timestamp":1462793300000},"page":"568-575","source":"Crossref","is-referenced-by-count":24,"title":["Genomewide profiling of copy\u2010number alteration in monoclonal gammopathy of undetermined significance"],"prefix":"10.1111","volume":"97","author":[{"given":"Aneta","family":"Mikulasova","sequence":"first","affiliation":[{"name":"Department of Experimental Biology Faculty of Science Masaryk University Brno Czech 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