{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:38:23Z","timestamp":1762659503162},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T00:00:00Z","timestamp":1467072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This retrospective study evaluates the impact of rituximab on <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content> response and survival in a single\u2010centre cohort. <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content> cases between 1984 and 2009, including heart, kidney, liver and lung transplant recipients, were included. Survival was analysed taking into account the type of <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content> (monomorphic vs. polymorphic), <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> infection status, <jats:styled-content style=\"fixed-case\">IPI<\/jats:styled-content> score, Ann Arbor stage and use of rituximab. Among 1335 transplanted patients, 24 developed <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>. Median age was 54 yr (range 29\u201369), median time to diagnosis 50 months (range 0\u2013100). <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content> type was predominantly late\/monomorphic (79% and 75%), mostly diffuse large B\u2010cell type. Overall response rate (<jats:styled-content style=\"fixed-case\">ORR<\/jats:styled-content>) was 62% (66% rituximab vs. 50% non\u2010rituximab; <jats:italic>P<\/jats:italic> = 0.5). R\u2010<jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content>\u2010like regimens were used most frequently (72% of patients treated with rituximab). Median overall survival was 64 months (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 95% 31\u201396). <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> was significantly increased in patients treated with rituximab (<jats:italic>P<\/jats:italic> = 0.01; <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 95% rituximab 58\u201379 months; non\u2010rituximab 1\u201330 months). Post\u2010transplant immunosuppression regimen had no effect on survival or time to <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>, except for cyclosporine A (CyA), which associated with increased time to <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.02). Rituximab was associated with increased survival in our single\u2010centre series, and it should be considered as first\u2010line therapy for <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content> patients. The possible protective effect of CyA for development of <jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content> should be prospectively evaluated.<\/jats:p>","DOI":"10.1111\/ejh.12782","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T14:42:51Z","timestamp":1464360171000},"page":"38-43","source":"Crossref","is-referenced-by-count":15,"title":["First\u2010line use of rituximab correlates with increased overall survival in late post\u2010transplant lymphoproliferative disorders: retrospective, single\u2010centre study"],"prefix":"10.1111","volume":"98","author":[{"given":"Nicol\u00e1s","family":"Mart\u00ednez\u2010Calle","sequence":"first","affiliation":[{"name":"Hematology Department Cl\u00ednica Universidad de Navarra Pamplona Espa\u00f1a"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Alfonso","sequence":"additional","affiliation":[{"name":"Hematology Department Cl\u00ednica Universidad de Navarra 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