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Due to novel agents, overall survival has improved in this group, yet there are no systematic reviews to understand the symptom profiles resulting from disease and treatment\u2010related toxicities. We aimed to synthesise data on the prevalence of symptoms in patients with<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic database and grey literature search were conducted in six databases. Random\u2010effects meta\u2010analysis with inverse variance weighting to pool prevalence data was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010six studies were included of which 34 studies (<jats:italic>N<\/jats:italic>= 3023) provided data for meta\u2010analysis. Twenty\u2010seven distinct symptoms were reported, with the majority of studies focusing on pain (<jats:italic>n<\/jats:italic>= 27), fatigue (<jats:italic>n<\/jats:italic>= 19) and problems with functioning (<jats:italic>n<\/jats:italic>= 15). The most prevalent symptoms were fatigue (98.8%, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>98.1\u201399.2%), pain (73%, 39.9\u201391.7), constipation (65.2%, 22.9\u201392.2) and tingling in the hands\/feet with 53.4% (0.4\u201399.7). The most common problems were decreased physical functioning (98.9%, 98.2\u201399.3), decreased cognitive functioning (80.2%, 40\u201396.1) and financial difficulties (78.4%, 39.1\u201395.4). These problems were present in newly diagnosed to advanced disease stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Optimal quality of life and good symptom management in this incurable disease can only be achieved by routinely assessing symptoms throughout the disease trajectory.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12790","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T08:26:40Z","timestamp":1471336000000},"page":"416-429","source":"Crossref","is-referenced-by-count":144,"title":["Prevalence of symptoms in patients with multiple myeloma: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"97","author":[{"given":"Christina","family":"Ramsenthaler","sequence":"first","affiliation":[{"name":"Department of Palliative Care, Policy and Rehabilitation Cicely Saunders Institute Faculty of Life Sciences and Medicine King's College London London UK"},{"name":"Department of Palliative Medicine Munich University Hospital Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Kane","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Policy and Rehabilitation Cicely Saunders Institute Faculty of Life Sciences and Medicine King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Policy and Rehabilitation Cicely Saunders Institute Faculty of Life Sciences and Medicine King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Siegert","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Policy and Rehabilitation Cicely Saunders Institute Faculty of Life Sciences and Medicine King's College London London UK"},{"name":"Department of Psychology Faculty of Health and Environmental Sciences Auckland University of Technology Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polly M.","family":"Edmonds","sequence":"additional","affiliation":[{"name":"Department of Palliative Care King's College Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Schey","sequence":"additional","affiliation":[{"name":"Department of Haematological Medicine King's College Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene J.","family":"Higginson","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Policy and Rehabilitation Cicely Saunders Institute Faculty of Life Sciences and Medicine King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,6]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Haematological Malignancy Research Network (HMRN).Epidemiology & cancer statistics group. 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