{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:52Z","timestamp":1787014132934,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T00:00:00Z","timestamp":1474329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To assess the effect of iron chelation therapy with deferasirox on cardiac iron and function in patients with transfusion\u2010dependent thalassemia major, sickle cell disease (\n                      <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\n                      ), and myelodysplastic syndromes (\n                      <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This phase\n                      <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                      , single\u2010arm, open\u2010label study over 53 wk evaluated the change in cardiac and liver iron load with deferasirox (up to 40 mg\/kg\/d), measured by magnetic resonance imaging (\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cardiac iron load (myocardial T2*) significantly improved (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.002) overall (\n                      <jats:italic>n<\/jats:italic>\n                      = 46;\n                      <jats:italic>n =<\/jats:italic>\n                      36 thalassemia major,\n                      <jats:italic>n =<\/jats:italic>\n                      4\n                      <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\n                      ,\n                      <jats:italic>n =<\/jats:italic>\n                      6\n                      <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>\n                      ). Results were significant for patients with normal and moderate baseline cardiac iron (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.017 and\n                      <jats:italic>P<\/jats:italic>\n                      = 0.015, respectively), but not in the five patients with severe cardiac iron load. Liver iron concentration (\n                      <jats:styled-content style=\"fixed-case\">LIC<\/jats:styled-content>\n                      ) significantly decreased overall [mean\n                      <jats:styled-content style=\"fixed-case\">LIC<\/jats:styled-content>\n                      10.4 to 8.2 mg Fe\/g dry tissue (dw);\n                      <jats:italic>P<\/jats:italic>\n                      = 0.024], particularly in those with baseline\n                      <jats:styled-content style=\"fixed-case\">LIC<\/jats:styled-content>\n                      &gt;7 mg Fe\/g dw (19.9 to 15.6 mg Fe\/g dw;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.002). Furthermore, myocardial T2* significantly increased in patients with\n                      <jats:styled-content style=\"fixed-case\">LIC<\/jats:styled-content>\n                      &lt;7 mg Fe\/g dw, but not in those with a higher\n                      <jats:styled-content style=\"fixed-case\">LIC<\/jats:styled-content>\n                      . Safety was consistent with previous reports.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Once\u2010daily deferasirox over 1 yr significantly increased myocardial T2* and reduced\n                      <jats:styled-content style=\"fixed-case\">LIC<\/jats:styled-content>\n                      . This confirms that single\u2010agent deferasirox is effective in the management of cardiac iron, especially for patients with myocardial T2* &gt;10 ms (Clinicaltrials.gov identifier:\n                      <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n                      00673608).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.12793","type":"journal-article","created":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T11:18:46Z","timestamp":1471519126000},"page":"97-105","source":"Crossref","is-referenced-by-count":10,"title":["Cardiac iron load and function in transfused patients treated with deferasirox (the\n                    <scp>MILE<\/scp>\n                    study)"],"prefix":"10.1111","volume":"98","author":[{"given":"P. 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Clinical Haematology Royal Melbourne Hospital Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4682-4972","authenticated-orcid":false,"given":"Tim","family":"St Pierre","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Radiology Royal Adelaide Hospital Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caro\u2010Anne","family":"Badcock","sequence":"additional","affiliation":[{"name":"Statistical Revelations Pty Ltd Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Traficante","sequence":"additional","affiliation":[{"name":"Statistical Revelations Pty Ltd Melbourne VIC 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