{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T12:49:03Z","timestamp":1702298943845},"reference-count":59,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T00:00:00Z","timestamp":1476144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research and Event Incentive Fund of Hospital de Cl\u00ednicas de Porto Alegre (FIPE-HCPA)"},{"name":"Sociedade Brasileira de Transplante de Medula \u00d3ssea (SBTMO)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Objectives<\/jats:title><jats:p>Acute myeloid leukemia (AML) accounts for 90% of all cases of acute leukemia in adults. In Brazil, the mortality from myeloid leukemia is 1.74\/100 000 men and 1.37\/100 000 women. Our aim was to review and update guidelines of the Brazilian Society of Bone Marrow Transplantation on indications of hematopoietic stem cell transplantation (HSCT) for the treatment AML.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>(i) Allo\u2010HSCT is recommended for high\u2010risk AML (IA); (ii) allo\u2010HSCT is recommended for AML of intermediate risk (IA); (iii) allo\u2010HSCT is recommended for AML relapsed\/refractory (C4); (iv) auto\u2010HSCT is recommended for AML after 1 consolidation (C4); (v) auto\u2010HSCT is recommended for AML in CR1 (higher than QT in the Brazilian experience) (C4); (vi) auto\u2010HSCT is accepted for AML M3 in second molecular complete remission (2B); (vii) peripheral blood instead of Bone Marrow HSC for advanced disease (2A); (viii) recommended conditioning protocols: Bu\u2010Cy\/Bu\u2010Mel, Bu\u2010Flu, TBI\u2010Cy. In umbilical cord HSCT, consider ATG\u2010based protocols (2A); (ix) allogeneic HSCT for the treatment of AML can be used in patients between 60 and 80 yr with good performance status and the absence of significant comorbidities (C4).<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12808","type":"journal-article","created":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T05:13:01Z","timestamp":1473743581000},"page":"177-183","source":"Crossref","is-referenced-by-count":2,"title":["Brazilian guidelines on hematopoietic stem cell transplantation in acute myeloid leukemia"],"prefix":"10.1111","volume":"98","author":[{"given":"Lucia","family":"Silla","sequence":"first","affiliation":[{"name":"Cellular Therapy Program HCPA Federal University of Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederico","family":"Dulley","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Unit Hospital Ingl\u00eas S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosaura","family":"Saboya","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Unit Hospital Ingl\u00eas S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Kerbauy","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplantation Unit Hospital Albert Einstein e UNIFESP S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"de Moraes Arantes","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplantation Unit Hospital Ara\u00fajo Jorge Goi\u00e3nia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelise","family":"Pezzi","sequence":"additional","affiliation":[{"name":"Cellular Therapy Program HCPA Federal University of Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa Grave","family":"Gross","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Paton","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Unit Hospital de Cancer de Barretos Barretos Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson","family":"Hamerschlak","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplantation Unit Hospital Albert Einstein e UNIFESP S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,11]]},"reference":[{"issue":"1","key":"e_1_2_17_2_1","article-title":"Diretrizes da Sociedade Brasileira de Transplante de Medula \u00d3ssea 2012: Sociedade Brasileira de Transplante de Medula \u00d3ssea. Angra dos Reis (RJ)","volume":"322","author":"Hamerschlak N","year":"2012","journal-title":"Palavra Impressa"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.52.1.23"},{"key":"e_1_2_17_4_1","unstructured":"N Howlader AM Noone M Krapcho National Cancer Institute Bethesda MD"},{"key":"e_1_2_17_5_1","unstructured":"Atlas on\u2010line of the INCa.On the other hand in the last estimate of mortality rate for cancer in Brazil.2014.http:\/\/www.inca.gov.br\/estimativa\/2014\/mapa.asp?ID=8 accessed in November 2014."},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(15)00028-9"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.18"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.12.012"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1590"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10738"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V75.3.555.555"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e32835423c3"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-096966"},{"key":"e_1_2_17_14_1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1182\/asheducation-2008.1.412","article-title":"Allogeneic hematopoietic cell transplantation for acute myeloid leukemia when a matched related donor is not available","volume":"1","author":"Appelbaum FR","year":"2008","journal-title":"Hematology Am Soc Hematol Edu Program"},{"key":"e_1_2_17_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjhh.2014.11.006"},{"key":"e_1_2_17_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjhh.2014.11.011"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-235358"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.150"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1301689"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24531"},{"key":"e_1_2_17_21_1","first-page":"232","article-title":"Validation of the EBMT risk score in chronic myloid leukemia in Brazil and allgeneic transplant oucome","volume":"90","author":"De Souza CA","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_17_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/565824"},{"key":"e_1_2_17_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29436"},{"key":"e_1_2_17_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.358"},{"key":"e_1_2_17_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-025627"},{"key":"e_1_2_17_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.813"},{"key":"e_1_2_17_27_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-84842010005000024"},{"key":"e_1_2_17_28_1","first-page":"11","article-title":"Estudo retrospectivo do tratamento de leucemia mieloide aguda com o transplante de medula \u00f3ssea: a experi\u00eancia brasileira","volume":"28","author":"Hamerschlak N","year":"2006","journal-title":"Rev Bras Hemat Hemoter"},{"key":"e_1_2_17_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-503847"},{"key":"e_1_2_17_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401800"},{"key":"e_1_2_17_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.51.8571"},{"key":"e_1_2_17_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.352"},{"key":"e_1_2_17_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.8121"},{"key":"e_1_2_17_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.9814"},{"key":"e_1_2_17_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.09.020"},{"key":"e_1_2_17_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-12-396275"},{"key":"e_1_2_17_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70352-3"},{"key":"e_1_2_17_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-024042"},{"key":"e_1_2_17_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12508"},{"key":"e_1_2_17_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.10.026"},{"key":"e_1_2_17_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.06.009"},{"key":"e_1_2_17_42_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.6856"},{"key":"e_1_2_17_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-381699"},{"key":"e_1_2_17_44_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041469"},{"key":"e_1_2_17_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.03.005"},{"key":"e_1_2_17_46_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-623991"},{"key":"e_1_2_17_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23995"},{"key":"e_1_2_17_48_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.8852"},{"key":"e_1_2_17_49_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-08-551499"},{"key":"e_1_2_17_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000120"},{"key":"e_1_2_17_51_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2015.972934"},{"key":"e_1_2_17_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.216"},{"key":"e_1_2_17_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11899-014-0211-8"},{"key":"e_1_2_17_54_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.762093"},{"key":"e_1_2_17_55_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0414"},{"key":"e_1_2_17_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.10.009"},{"key":"e_1_2_17_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.06.005"},{"key":"e_1_2_17_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.08.005"},{"key":"e_1_2_17_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.03.009"},{"key":"e_1_2_17_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.02.007"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12808","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12808","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:20:02Z","timestamp":1696332002000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,11]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/ejh.12808"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12808","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,11]]}}}