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However, some patients may show gains on several chromosomes simultaneously suggesting a hyperdiploid karyotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to analyse by <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content> the frequency and prognostic impact of hyperdiploidy in <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A review of 1359 consecutive cases diagnosed with <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> referred for <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content> analysis to a unique institution was carried out. Hyperdiploidy was considered when a gain of at least three of the five <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content> probes used was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven cases (0.51%) with hyperdiploidy were found, confirming that it is a rare event in this disease. Although most patients presented with early Binet stages at diagnosis, six of seven (86%) shortly progressed. The median of time to the first therapy (<jats:styled-content style=\"fixed-case\">TTFT<\/jats:styled-content>) and overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) for the patients with hyperdiploidy were short (1.4 months and 20 months, respectively). Moreover, comparing them with a control group of patients (non\u2010hyperdiploid) with completed follow\u2010up data, <jats:styled-content style=\"fixed-case\">TTFT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> of the patients with hyperdiploidy were significantly shorter than the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of hyperdiploidy is uncommon and probably associated with poor prognostic markers in <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12812","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T14:01:17Z","timestamp":1474898477000},"page":"142-148","source":"Crossref","is-referenced-by-count":4,"title":["Hyperdiploidy as a rare event that accompanies poor prognosis markers in 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