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Serum levels of 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D<jats:sub>3<\/jats:sub>, the precursor to the active form of vitamin D, calcitriol, are frequently lower in patients with hematological disease compared to healthy individuals. This often correlates with worse disease outcome. Furthermore, diseased cells typically highly express the vitamin D receptor, which is required for many of the anti\u2010cancer effects observed in multiple <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> cancer models. In abnormal hematological cells, vitamin D supplementation promotes apoptosis, induces differentiation, inhibits proliferation, sensitizes tumor cells to other anti\u2010cancer therapies, and reduces the production of pro\u2010inflammatory cytokines. Although the dosage of vitamin D required to achieve these effects may induce hypercalcemia in humans, analogs and combinatorial treatments have been developed to circumvent this side effect. Vitamin D and its analogs are well tolerated in clinical trials, and thus, further investigation into the use of these agents in the clinic is warranted. Here, we review the current literature in this field.<\/jats:p>","DOI":"10.1111\/ejh.12818","type":"journal-article","created":{"date-parts":[[2016,10,15]],"date-time":"2016-10-15T07:02:55Z","timestamp":1476514975000},"page":"187-197","source":"Crossref","is-referenced-by-count":73,"title":["Vitamin D in hematological disorders and malignancies"],"prefix":"10.1111","volume":"98","author":[{"given":"Paige M.","family":"Kulling","sequence":"first","affiliation":[{"name":"University of Virginia Cancer Center University of Virginia Charlottesville VA USA"},{"name":"Division of Hematology\/Oncology Department of Medicine University of Virginia Charlottesville VA USA"},{"name":"Department of Pathology University of Virginia Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine C.","family":"Olson","sequence":"additional","affiliation":[{"name":"University of Virginia Cancer Center University of Virginia Charlottesville VA USA"},{"name":"Division of Hematology\/Oncology Department of Medicine University of Virginia Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Olson","sequence":"additional","affiliation":[{"name":"University of Virginia Cancer Center University of Virginia Charlottesville VA USA"},{"name":"Division of Hematology\/Oncology Department of Medicine University of Virginia Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4981-1691","authenticated-orcid":false,"given":"David J.","family":"Feith","sequence":"additional","affiliation":[{"name":"University of Virginia Cancer Center University of Virginia Charlottesville VA USA"},{"name":"Division of Hematology\/Oncology Department of Medicine University of Virginia Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Thomas 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