{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:57:23Z","timestamp":1792526243697,"version":"4.5.0"},"reference-count":3,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Haemorrhagic cystitis caused by BK<\/jats:styled-content> virus (BKV<\/jats:styled-content>) is a known complication of allogeneic haematopoietic cell transplantation (HCT<\/jats:styled-content>) and is relatively common following HLA\u2010haploidentical transplantation. Adoptive immunotransfer of virus\u2010specific T cells from the donor is a promising therapeutic approach, although production of these cells is challenging, particularly when dealing with low\u2010frequency T cells such as BKV<\/jats:styled-content>\u2010specific T cells.<\/jats:p><\/jats:sec>Case report<\/jats:title>Here, we present a patient who, following haploidentical HCT<\/jats:styled-content>, developed severe BKV<\/jats:styled-content> haemorrhagic cystitis, resistant to standard therapy. He responded well to adoptive transfer of donor cells enriched in BKV<\/jats:styled-content>\u2010specific T cells using the new second\u2010generation CliniMACS<\/jats:styled-content> Prodigy and the Cytokine Capture System from Miltenyi Biotec. Treatment led to full resolution of both the symptoms and viraemia without unwanted complications.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our observations suggest that use of products enriched with BKV<\/jats:styled-content>\u2010specific T cells generated using this system is safe and efficient in HLA\u2010haploidentical HCT<\/jats:styled-content> where BKV<\/jats:styled-content> cystitis can be a serious complication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12848","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T15:18:34Z","timestamp":1484320714000},"page":"632-634","source":"Crossref","is-referenced-by-count":43,"title":["BKV\u2010specific T cells in the treatment of severe refractory haemorrhagic cystitis after HLA\u2010haploidentical haematopoietic cell transplantation"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6519-2598","authenticated-orcid":false,"given":"Oscar M.","family":"Pello","sequence":"first","affiliation":[{"name":"Centre for Haematology Imperial College at Hammersmith Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Innes","sequence":"additional","affiliation":[{"name":"Centre for Haematology Imperial College at Hammersmith Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Bradshaw","sequence":"additional","affiliation":[{"name":"Centre for Haematology Imperial College at Hammersmith Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally\u2010Anne","family":"Finn","sequence":"additional","affiliation":[{"name":"Centre for Haematology Imperial College at Hammersmith Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shab","family":"Uddin","sequence":"additional","affiliation":[{"name":"Centre for Haematology Imperial College at Hammersmith Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Bray","sequence":"additional","affiliation":[{"name":"Centre for Haematology Imperial College at Hammersmith Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Olavarria","sequence":"additional","affiliation":[{"name":"Centre for Haematology Imperial College at Hammersmith Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane F.","family":"Apperley","sequence":"additional","affiliation":[{"name":"Centre for Haematology Imperial College at Hammersmith Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159\u00ed","family":"Pavl\u016f","sequence":"additional","affiliation":[{"name":"Centre for Haematology Imperial College at Hammersmith Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/972102"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-628982"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-014-0348-z"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12848","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T15:52:29Z","timestamp":1696348349000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":3,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/ejh.12848"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12848","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]}}}