{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:18:37Z","timestamp":1787847517350,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T00:00:00Z","timestamp":1488499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["No. 16K19093"],"award-info":[{"award-number":["No. 16K19093"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>T\u2010cell prolymphocytic leukemia (T\u2010<jats:styled-content style=\"fixed-case\">PLL<\/jats:styled-content>) is a very rare, aggressive T\u2010cell neoplasm. Peripheral T\u2010cell lymphoma, not otherwise specified (<jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>) is also a highly aggressive lymphoma. These two diseases can often be confused with each other; therefore, we aimed to determine the clinical and pathological differences between T\u2010<jats:styled-content style=\"fixed-case\">PLL<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 15 T\u2010<jats:styled-content style=\"fixed-case\">PLL<\/jats:styled-content>and 91<jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>patients and also compared clinical features between T\u2010<jats:styled-content style=\"fixed-case\">PLL<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>with leukemic presentation. Peripheral blood images and biopsy specimens were analyzed, and treatment responses were determined via imaging modalities. The clinicopathological characteristics were statistically compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>T\u2010PLL cells were smaller in size than those of<jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>with leukemic presentation (<jats:italic>P<\/jats:italic>=.0068); moreover,<jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>cells with leukemic presentation were smaller than those of<jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>without leukemic presentation (<jats:italic>P<\/jats:italic>=.0017). Immunophenotypic patterns in T\u2010<jats:styled-content style=\"fixed-case\">PLL<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>were similar. Five\u2010year overall survival rates of T\u2010<jats:styled-content style=\"fixed-case\">PLL<\/jats:styled-content>and all<jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>patients were 57.5% and 36.8%, respectively. No significant differences were found in clinical manifestations or prognoses; T\u2010<jats:styled-content style=\"fixed-case\">PLL<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>with leukemic presentation had essentially equivalent characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>T\u2010PLL and<jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>may share common biological and clinical characteristics in Japanese patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12856","type":"journal-article","created":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T21:37:47Z","timestamp":1485553067000},"page":"459-466","source":"Crossref","is-referenced-by-count":14,"title":["Comparison of clinicopathological characteristics between T\u2010cell prolymphocytic leukemia and peripheral T\u2010cell lymphoma, not otherwise specified"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9040-285X","authenticated-orcid":false,"given":"Keisuke","family":"Kawamoto","sequence":"first","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"},{"name":"Department of Hematology, Endocrinology, and Metabolism Faculty of Medicine Niigata University Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Yanagida","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume 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