{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:21:40Z","timestamp":1760955700478,"version":"3.37.3"},"reference-count":7,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T00:00:00Z","timestamp":1490918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Inherited chromosomally integrated human herpesvirus\u20106 (ci<jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106) is characterised by the complete <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106 genome integration into the host germ line genome and is vertically transmitted with a Mendelian inheritance. By now, the only relationship between ci<jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106 and diseases seems to be with angina pectoris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report a case of an 82\u2010year\u2010old man diagnosed with diffuse large B\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>) on October 2014. To substantiate the suspicion of ci<jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106, we analysed peripheral blood mononuclear cells, bone marrow biopsy and pleural effusion\u2010derived mesothelial cells with <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Virological routine screening by <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> showed the absence of <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20108 and <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> infections, while the presence of <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106 <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> (ie, U22, U42 and U94 <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106 genes), with a viral load of about 1.0 genome per cell, strongly suggests ci<jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106. The <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> showed the positivity only for the immediate\u2010early U94, at low levels of transcription (100\u00b115\u00a0transcripts\/1\u00a0\u03bcg <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content> analysis reported a case of inherited ci<jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106 in 17p chromosome region and, for the first time, in a marker chromosome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first case of inherited ci<jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106 in a marker chromosome, possibly elucidating the role of this abnormality in the biology of <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12872","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T08:02:40Z","timestamp":1488268960000},"page":"635-637","source":"Crossref","is-referenced-by-count":5,"title":["Detection of inherited chromosomally integrated <scp>HHV<\/scp>\u20106 (ci<scp>HHV<\/scp>\u20106) in a marker chromosome"],"prefix":"10.1111","volume":"98","author":[{"given":"Diana","family":"Campioni","sequence":"first","affiliation":[{"name":"Section of Microbiology University of Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Gentili","sequence":"additional","affiliation":[{"name":"Section of Haematology University of Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Cavazzini","sequence":"additional","affiliation":[{"name":"Section of Microbiology University of Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daria","family":"Bortolotti","sequence":"additional","affiliation":[{"name":"Section of Haematology University of Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth P.","family":"Nacheva","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal Free &amp; University College Medical School  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Cuneo","sequence":"additional","affiliation":[{"name":"Section of Microbiology University of Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Di Luca","sequence":"additional","affiliation":[{"name":"Section of Haematology University of Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9507-9126","authenticated-orcid":false,"given":"Roberta","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Section of Haematology University of Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,31]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.715"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1502741112"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-013-1902-5"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158304"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12257"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21299"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.7.2554"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12872","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T15:52:26Z","timestamp":1696348346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,31]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/ejh.12872"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12872","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"type":"print","value":"0902-4441"},{"type":"electronic","value":"1600-0609"}],"subject":[],"published":{"date-parts":[[2017,3,31]]}}}