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Healthcare payers seek cost\u2010offsets from therapies that improve clinical outcomes but challenge budgets; employers seek lower absenteeism and better productivity. Study goals were to: (i) identify direct and indirect economic factors of <jats:styled-content style=\"fixed-case\">RRMM<\/jats:styled-content>, and (ii) explore longitudinal relationships between clinical, economic, and health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL) assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Economic questionnaire, clinical, and <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL data from a multisite, international, randomized, controlled study in <jats:styled-content style=\"fixed-case\">RRMM<\/jats:styled-content> were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients (n=263) were 53.6% male, 91.6% Caucasian; mean age of 62.9\u00a0years, median Eastern Cooperative Oncology Group status of 1 (56.3%). Moderate to severe pain or fatigue was reported by 30.4% and 70.6%, respectively. At baseline, \u22651 hospitalization was reported by 107 (41.8%); 182 (71.1%) and 86 (33.6%) reported specialist and family physician visits, respectively. A total of 28 (10.8%) were working: 10 (37.0%) of which reported <jats:styled-content style=\"fixed-case\">RRMM<\/jats:styled-content>\u2010driven absenteeism \u22651\u00a0day. Of those who were not working, 110 (48.2%) indicated that it was due to <jats:styled-content style=\"fixed-case\">RRMM<\/jats:styled-content>. Multivariate modeling showed lower hospitalization with a major tumor response (\u03b2=\u22121.44, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u22122.89 to 0.01, <jats:italic>P<\/jats:italic>=.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Substantial <jats:styled-content style=\"fixed-case\">RRMM<\/jats:styled-content> indirect, social costs were observed. Better major tumor response may reduce hospital visits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12876","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T14:32:48Z","timestamp":1489761168000},"page":"119-132","source":"Crossref","is-referenced-by-count":15,"title":["Economic burden of relapsed or refractory multiple myeloma: Results from an international trial"],"prefix":"10.1111","volume":"99","author":[{"suffix":"Jr","given":"Don","family":"Robinson","sequence":"first","affiliation":[{"name":"Janssen Global Services  Raritan NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Z.","family":"Orlowski","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Stokes","sequence":"additional","affiliation":[{"name":"Evidera  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"He","sequence":"additional","affiliation":[{"name":"Janssen Global Services  Raritan NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Huse","sequence":"additional","affiliation":[{"name":"Evidera  Waltham MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Chitnis","sequence":"additional","affiliation":[{"name":"Evidera  Waltham MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britte","family":"Kranenburg","sequence":"additional","affiliation":[{"name":"Janssen Research and Development  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Lam","sequence":"additional","affiliation":[{"name":"Janssen Global Services  Raritan NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12020"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2008.09.003"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0b013e3182693522"},{"issue":"1","key":"e_1_2_8_5_1","first-page":"214","article-title":"A Multinational Observational study in Multiple Myeloma (PREAMBLE): assessment of Disease Impact on Work Productivity and Activity","volume":"99","author":"Moreau P","year":"2014","journal-title":"Haematologica"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0113"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.380"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23868"},{"issue":"7","key":"e_1_2_8_9_1","first-page":"19","article-title":"Economic and clinical impact of multiple myeloma to managed care","volume":"14","author":"Cook R","year":"2008","journal-title":"J Manag Care Pharm"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130864"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23541"},{"key":"e_1_2_8_12_1","first-page":"849","article-title":"Functional status and radiographic joint damage are associated with health economic outcomes in patients with rheumatoid arthritis","volume":"31","author":"Kavanaugh A","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22044"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21661"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22097"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.185"},{"key":"e_1_2_8_17_1","unstructured":"FACIT.The Functional Assessment of Chronic Illness Therapy\u2010Fatigue (FACIT\u2010Fatigue) Scale: Summary of development and validation. 2013 September 3; 11\u201020.www.facit.org. 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