{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:33:11Z","timestamp":1792153991474,"version":"4.4.0"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Multiple myeloma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>) patients report high symptom burden and reduced health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL) compared to patients with other haematological malignancies. The aim of this review was to analyse published longitudinal studies including <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> patients according to a change in <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL scores, which is perceived as beneficial to the patient according to two published guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search was performed May 2016. Publications with longitudinal follow\u2010up using the <jats:styled-content style=\"fixed-case\">EORTC QLQ<\/jats:styled-content>\u2010C30 instrument for <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL measurement of physical functioning, global quality of life, fatigue and\/or pain were included. An analysis of mean change from baseline was carried out according to minimal important difference (<jats:styled-content style=\"fixed-case\">MID<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Large and medium <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL improvements were reported during first\u2010line treatments. No clinically beneficial change or deteriorations in scores of global QoL or fatigue were reported during relapse treatment. <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL data during maintenance therapy are sparse and inconclusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Guidelines for interpreting changes in <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL including definitions of <jats:styled-content style=\"fixed-case\">MID<\/jats:styled-content> have been developed; however, consensus is missing. Improvements in <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL are far more likely to occur during first\u2010line compared to relapsed treatment regimens. The background of these findings should be in focus in future studies, and <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL measurements should be integrated in maintenance studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12882","type":"journal-article","created":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T10:35:33Z","timestamp":1490092533000},"page":"3-17","source":"Crossref","is-referenced-by-count":69,"title":["A systematic review of health\u2010related quality of life in longitudinal studies of myeloma patients"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2083-3870","authenticated-orcid":false,"given":"Lene Kongsgaard","family":"Nielsen","sequence":"first","affiliation":[{"name":"Quality of Life Research Centre Department of Haematology Odense University Hospital  Odense Denmark"},{"name":"The Academy of Geriatric Cancer Research (AgeCare) Odense University Hospital  Odense 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