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Apart from acute pulmonary histoplasmosis and involvement of the central nervous system, the most serious clinical presentation is progressive disseminated histoplasmosis which is generally associated with severe immunodeficiency and, in particular, advanced human immunodeficiency virus infection. Here, we report on an immunocompetent female residing in a non\u2010endemic area, presenting with progressive disseminated histoplasmosis after a remote travel history to Thailand and Costa Rica. Diagnosis was delayed by several months due to misinterpretation of epithelioid cell granulomatosis of the intestine as Crohn's disease and of similar lung lesions as acute sarcoidosis. Prompted by clinical deterioration with signs and symptoms consistent with hemophagocytic lymphohistiocytosis, a bone marrow aspiration was performed that documented hemophagocytosis and intracellular organisms interpreted as <jats:italic>Leishmania<\/jats:italic> sp., but later identified by molecular methods as <jats:italic>Histoplasma capsulatum<\/jats:italic>. Treatment with liposomal amphotericin B followed by posaconazole led to prompt clinical improvement and ultimately cure.<\/jats:p>","DOI":"10.1111\/ejh.12886","type":"journal-article","created":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T02:29:11Z","timestamp":1490668151000},"page":"91-100","source":"Crossref","is-referenced-by-count":21,"title":["Progressive histoplasmosis with hemophagocytic lymphohistiocytosis and epithelioid cell granulomatosis: A case report and review of the literature"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1644-3573","authenticated-orcid":false,"given":"Arik Bernard","family":"Schulze","sequence":"first","affiliation":[{"name":"Department of Medicine A University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Heptner","sequence":"additional","affiliation":[{"name":"Department of Medicine A University Hospital Muenster  Muenster 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