{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:30:08Z","timestamp":1788201008411,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T00:00:00Z","timestamp":1493942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["#1005"],"award-info":[{"award-number":["#1005"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the financial and psycho\u2010social impact of participation in clinical trials of patients with <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content><\/jats:italic>\u2010negative myeloproliferative neoplasms (<jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An international, observational cross\u2010sectional study was performed in 143 consecutive <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content> patients (51% myelofibrosis, 36% polycythemia vera, 13% essential thrombocythemia), 68% from Italy, 17% from <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content>, and 15% from Spain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010five percent of patients reported having spent more money during the trial than in previous treatments and 21% having missed more workdays. Twelve percent replied that they would not have participated in the trial if the financial consequences would have been known beforehand. In 10% of the patients, the interpersonal relationships were more affected during the trial than in previous treatment but, overall, 91% subjects believed that participating in the clinical trial was worth the financial or emotional suffering. Concerning patients\u2019 suggestions, 54% of them indicated that the number of visits required for the trial should be clearly specified in the informed consent, 60% recommended travel cost reimbursement, and 23% hotel cost reimbursement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Physicians and pharmaceutical companies involved in clinical trials with patients with hematological diseases should be aware of these problems and make efforts to attenuate the socioeconomic burden of participation in the trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12887","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T21:52:56Z","timestamp":1491256376000},"page":"36-41","source":"Crossref","is-referenced-by-count":8,"title":["Socioeconomic burden of participation in clinical trials in patients with myeloproliferative neoplasms"],"prefix":"10.1111","volume":"99","author":[{"given":"Swati","family":"Goel","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Montefiore Medical Center  Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Paoli","sequence":"additional","affiliation":[{"name":"Center of Research and Innovation of Myeloproliferative Neoplasms, AOU Careggi University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Iurlo","sequence":"additional","affiliation":[{"name":"Oncohematology Division IRCCS Ca\u2019 Granda\u2010Maggiore Policlinico Hospital Foundation  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Pereira","sequence":"additional","affiliation":[{"name":"Hemostasis Department Hospital Cl\u00ednic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Efficace","sequence":"additional","affiliation":[{"name":"GIMEMA Data Center and Health Outcomes Research Unit  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziano","family":"Barbui","sequence":"additional","affiliation":[{"name":"Research Foundation Ospedale Papa Giovanni XXII  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayalew","family":"Tefferi","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine \u00a0Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro M.","family":"Vannucchi","sequence":"additional","affiliation":[{"name":"Center of Research and Innovation of Myeloproliferative Neoplasms, AOU Careggi University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2664-8131","authenticated-orcid":false,"given":"Francisco","family":"Cervantes","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic, IDIBAPS University of Barcelona  Barcelona 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