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Fifteen patients received additional pre\u2010emptive\/rescue administration of plerixafor. Stem cell collection was successful (\u22652\u00d7106<\/jats:sup> CD<\/jats:styled-content>34+ cells per kg\u00a0bw) in 77% (23\/30 patients). Patients with prior high\u2010dose melphalan collected a significantly lower median total number of PBSC<\/jats:styled-content>s than patients without prior high\u2010dose melphalan (3.3\u00d7106<\/jats:sup> vs 17\u00d7106<\/jats:sup> CD<\/jats:styled-content>34+ cells\/kg\u00a0bw). Toxicity of HD\u2010CY was frequent with 12 serious adverse events (SAE<\/jats:styled-content>) in 37% of patients (11\/30 patients). Infections accounted for the majority of SAE<\/jats:styled-content> reports. In two patients, SAE<\/jats:styled-content>s were lethal (septic shock).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>These data proof feasibility of PBSC<\/jats:styled-content> collection at relapse but emphasize the importance of collection and storage of additional PBSC<\/jats:styled-content> transplants during first\u2010line treatment when mobilization is more efficient and less toxic.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12888","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T21:49:47Z","timestamp":1491256187000},"page":"42-50","source":"Crossref","is-referenced-by-count":20,"title":["Cyclophosphamide\u2010based stem cell mobilization in relapsed multiple myeloma patients: A subgroup analysis from the phase III<\/scp> trial ReLA<\/scp>psE"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4000-6904","authenticated-orcid":false,"given":"Marc\u2010Andrea","family":"Baertsch","sequence":"first","affiliation":[{"name":"Department of Medicine V University Hospital Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Schlenzka","sequence":"additional","affiliation":[{"name":"Department of Medicine V University Hospital Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Lisenko","sequence":"additional","affiliation":[{"name":"Department of Medicine V University Hospital Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Krzykalla","sequence":"additional","affiliation":[{"name":"Biostatistics German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Becker","sequence":"additional","affiliation":[{"name":"Biostatistics German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Weisel","sequence":"additional","affiliation":[{"name":"Hematology, Oncology and Immunology University of Tuebingen Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Noppeney","sequence":"additional","affiliation":[{"name":"Hematology University Hospital Essen Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Martin","sequence":"additional","affiliation":[{"name":"Hematology and Oncology Goethe University Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans W.","family":"Lindemann","sequence":"additional","affiliation":[{"name":"Hematology and Oncology Kath. 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