{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:33:05Z","timestamp":1776691985037,"version":"3.51.2"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T00:00:00Z","timestamp":1495584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001253","name":"Multiple Myeloma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>To identify germ line variants contributing to the development of monoclonal gammopathy of undetermined significance (MGUS<\/jats:styled-content>), an asymptomatic premalignant precursor for multiple myeloma (MM<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>We conducted the first genomewide association study (GWAS<\/jats:styled-content>) on MGUS<\/jats:styled-content> on 243 German cases with a replication on 294 Czech cases. Identified loci were further analyzed in 1508 German MM<\/jats:styled-content> patients. New MM<\/jats:styled-content> loci recently reported in a meta\u2010analysis were also tested in the MGUS GWAS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>In GWAS<\/jats:styled-content>, we identified 10 loci contributing to development of MGUS<\/jats:styled-content> at P<\/jats:italic>\u2010value threshold of 10\u22125<\/jats:sup>. The Czech cohort gave support for two associations (6q26, rs6933936; 7p21.3 rs10251201). In GWAS<\/jats:styled-content>, rs974120 (8p23.2) reached genomewide significance (P<\/jats:italic>=2.94\u00d710\u22129<\/jats:sup>), with a nominal significance in MM<\/jats:styled-content>. The locus of rs974120 shows marks of transcriptional activity in leukemia according to ENCODE<\/jats:styled-content> data. rs10251201 (7p21.3), rs9318227 (13q22.1), and rs10405859 (19q13.32) were associated with markers related to leukemogenesis and immune and inflammatory responses. Two newly identified candidate loci for MM<\/jats:styled-content>, rs1948915 (8q24.21) and rs8058578 (16p11.2), were nominally associated with MGUS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>These data allow a cautious first proposal for a germ line architecture of MGUS<\/jats:styled-content> with links to leukemia and autoimmune conditions, the latter agreeing with a family study showing clustering of MGUS<\/jats:styled-content> with autoimmune diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12892","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T17:02:47Z","timestamp":1491411767000},"page":"70-79","source":"Crossref","is-referenced-by-count":19,"title":["Genomewide association study on monoclonal gammopathy of unknown significance (MGUS)"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5951-3116","authenticated-orcid":false,"given":"Hauke","family":"Thomsen","sequence":"first","affiliation":[{"name":"Division of Molecular Genetic Epidemiology German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Campo","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetic Epidemiology German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Weinhold","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V University of Heidelberg Heidelberg Germany"},{"name":"Myeloma Institute University of Arkansas for Medical Sciences Little Rock AR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Inacio","family":"da Silva Filho","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetic Epidemiology German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lud\u011bk","family":"Pour","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hematology and Oncology University Hospital Brno Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ev\u017een","family":"Gregora","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital Kralovske Vinohrady Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Vodicka","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine Academy of Sciences of the Czech Republic Prague Czech Republic"},{"name":"Institute of Biology and Medical Genetics 1st<\/sup> Medical Faculty Charles University Prague Czech 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