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MCAS presents as chronic, generally inflammatory multisystem polymorbidity likely driven in most by heterogeneous patterns of constitutively activating mutations in MC regulatory elements, posing challenges for identifying optimal mutation\u2010targeted treatment in individual patients. Targeting commonly affected downstream effectors may yield clinical benefit independent of upstream mutational profile. For example, both activated KIT and numerous cytokine receptors activate the Janus kinases (JAKs). Thus, JAK\u2010inhibiting therapies may be useful against the downstream inflammatory effects of MCAS. The oral JAK1\/JAK3 inhibitor, tofacitinib, is currently approved for rheumatoid arthritis and is in clinical trials for other chronic inflammatory disorders. Herein, we report two patients with MCAS who rapidly gained substantial symptomatic response to tofacitinib. Their improvement suggests need for further evaluation of this class of drugs in MCAS treatment.<\/jats:p>","DOI":"10.1111\/ejh.12893","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T05:20:26Z","timestamp":1491456026000},"page":"190-193","source":"Crossref","is-referenced-by-count":11,"title":["Successful targeted treatment of mast cell activation syndrome with tofacitinib"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3550-4244","authenticated-orcid":false,"given":"Lawrence B.","family":"Afrin","sequence":"first","affiliation":[{"name":"Division of Hematology, Oncology and Transplantation University of Minnesota  Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger W.","family":"Fox","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology University of South Florida  Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Zito","sequence":"additional","affiliation":[{"name":"Suncoast Internal Medicine Consultants  Largo FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Choe","sequence":"additional","affiliation":[{"name":"Suncoast Internal Medicine Consultants  Largo FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C.","family":"Glover","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel and Celiac Disease Program University of Florida  Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2016.12.013"},{"key":"e_1_2_7_3_1","unstructured":"Xeljanz(R)[package insert].Pfizer Laboratories New York NY February 2016.http:\/\/labeling.pfizer.com\/ShowLabeling.aspx?id=959. 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