{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T13:46:25Z","timestamp":1776260785346,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T00:00:00Z","timestamp":1494460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health, Czech Republic","award":["65269705"],"award-info":[{"award-number":["65269705"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Monoclonal gammopathy of undetermined significance (<jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content>) is a premalignant condition with a risk of malignant conversion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>With the aim to estimate the cumulative risk <jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content> progression to hematologic malignancies, we analyzed a nationwide population\u2010based\u00a0cohort of 1887 <jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content> patients from the Czech Registry of Monoclonal Gammopathies (<jats:styled-content style=\"fixed-case\">RMG<\/jats:styled-content>) between 2007 and 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the follow\u2010up period (median 4\u00a0years; range 0.6\u201034.8), progression to hematologic malignancies was observed in 8.6% (162 of 1887) of patients. Factors associated with progression were as follows: M\u2010protein concentration \u22651.5\u00a0g\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>, pathological <jats:styled-content style=\"fixed-case\">sFLC<\/jats:styled-content> (&lt;0.26 or &gt;1.65) ratio, bone marrow plasma cells (<jats:styled-content style=\"fixed-case\">BMPC<\/jats:styled-content>s) in cytology &gt;5%, immunoparesis, age \u226569\u00a0years, and the level of serum hemoglobin at baseline &lt;12.0\u00a0g\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>. Combining these factors, we propose a new risk model (<jats:styled-content style=\"fixed-case\">CMG<\/jats:styled-content> model). The risk of progression at 10\u00a0years was 1.6%, 16.9%, 22.9%, 39.4%, and 52.3%, respectively, if 0 (reference group), one, two, three, or four to five risk factors are present (<jats:italic>P<\/jats:italic>&lt;.001) with <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 63 times higher compared to the reference <jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The new <jats:styled-content style=\"fixed-case\">CMG<\/jats:styled-content> model was established with an advantage for better identification of <jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content> patients at low risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12894","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T19:03:56Z","timestamp":1491505436000},"page":"80-90","source":"Crossref","is-referenced-by-count":8,"title":["A first Czech analysis of 1887 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