{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:48:46Z","timestamp":1780598926726,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Aim of this retrospective study was to analyze the dynamics of <jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV reactivation in allogeneic hematopoietic stem cell transplant recipients in order to identify patients with higher risk to develop <jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV\u2010associated hemorrhagic cystitis (<jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV\u2010associated <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 58 allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients from the University Hospital of Cologne detected <jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV positive by real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> between 2009 and 2015. For correlative analysis, the first detected <jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV\u2010<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> load in urine and in plasma as well as the onset and severity of <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> following the first day of conditioning regimen was considered. Phylogenetic analysis of <jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV isolates was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 25 of 58 patients, <jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV\u2010<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was detected in urine only (group U), whereas 33 patients developed additional viremia (group P). A chronologic sequence viruria\u2010viremia\u2010<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> was identified. Viral load of &gt;10<jats:sup>6<\/jats:sup> copies\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> at first viruria and evidence of viremia after 45\u00a0days from the start of conditioning represented risk factors for the onset of <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>. Molecular characterization revealed a non\u2010stereotypic distribution of viral subtypes across groups U and P.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Monitoring of <jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV\u2010<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> by real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> after initiation of conditioning, regularly performed in clinical practice, can be a crucial tool for the early identification of patients with higher risk of <jats:styled-content style=\"fixed-case\">BKP<\/jats:styled-content>yV\u2010associated <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12895","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T07:12:41Z","timestamp":1491981161000},"page":"133-140","source":"Crossref","is-referenced-by-count":12,"title":["Dynamics of <scp>BKP<\/scp>yV reactivation and risk of hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"99","author":[{"given":"Konstantin","family":"H\u00f6ller","sequence":"first","affiliation":[{"name":"Institute of Virology University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia","family":"Fabeni","sequence":"additional","affiliation":[{"name":"National Institute for Infectious Diseases L. 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