{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:57:00Z","timestamp":1791327420842,"version":"4.3.1"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:00:00Z","timestamp":1498003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007658","name":"Baxter Healthcare Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007658","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to describe the current management and outcomes of patients with secondary immunodeficiencies (SID) on intravenous (IV) or subcutaneous (SC) immunoglobulins (IG) as maintenance therapy to prevent infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Non\u2010interventional, prospective study (average follow\u2010up 20.5\u00a0months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 307 SID patients (mean age 63.7\u00b114.4\u00a0years, 52% males, in 31% IG newly initiated), 95.4% received IV IG (mean dosing interval 4.6\u00a0weeks, average dose 199\u00a0mg\/kg per 4\u00a0weeks) and 4.6% were treated with SC IG (2.6\u00a0weeks, 343\u00a0mg\/kg per 4\u00a0weeks). Median IG through level at first documentation was 5.8\u00a0g\/L and did not differ between IV and SC treatment or between underlying malignancies. In 24.1% of patients, treatment was interrupted temporarily, over a mean of 11.6\u00b16.3\u00a0months. In patients with newly initiated IG treatment the 82% overall infection rate prior to treatment dropped to 21% at 1\u00a0year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Under clinical practice conditions, IG replacement therapy in SID patients was feasible, diminished infection rates and improved quality of life. Average IG doses were relatively low. Tolerability of IV IG treatment was excellent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12900","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T14:26:48Z","timestamp":1493821608000},"page":"169-177","source":"Crossref","is-referenced-by-count":33,"title":["Management of patients with malignancies and secondary immunodeficiencies treated with immunoglobulins in clinical practice: Long\u2010term data of the SIGNS study"],"prefix":"10.1111","volume":"99","author":[{"given":"Marcel","family":"Reiser","sequence":"first","affiliation":[{"name":"PIOH \u2010 Praxis internistischer Onkologie und H\u00e4matologie  K\u00f6ln Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Borte","sequence":"additional","affiliation":[{"name":"Paediatric Rheumatology, Immunology and Infectiology Hospital St. Georg  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00f6rte","family":"Huscher","sequence":"additional","affiliation":[{"name":"Epidemiology unit German Rheumatism Research Centre A Leibniz institute  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Baumann","sequence":"additional","affiliation":[{"name":"Paediatric Pulmonology, Allergy and Neonatology Hanover Medical School  Hanover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1136-2616","authenticated-orcid":false,"given":"David","family":"Pittrow","sequence":"additional","affiliation":[{"name":"Medical Faculty Institute for Clinical Pharmacology Technical University Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sommer","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Stangel","sequence":"additional","affiliation":[{"name":"Department of Neurology Hanover Medical School  Hanover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Fasshauer","sequence":"additional","affiliation":[{"name":"Paediatric Rheumatology, Immunology and Infectiology Hospital St. Georg  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Gold","sequence":"additional","affiliation":[{"name":"Department for Neurology St. Josef\u2010Hospital Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Hensel","sequence":"additional","affiliation":[{"name":"Mannheimer Onkologie Praxis  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.23.2810"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00626"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldn034"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29438"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04497.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.126763"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070389"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13532"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.107714"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2009.01154.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1994.tb01874.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000227231"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198810063191403"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1182\/blood.V73.2.366.366","article-title":"Crossover study of immunoglobulin replacement therapy in patients with low\u2010grade B\u2010cell tumors","volume":"73","author":"Griffiths H","year":"1989","journal-title":"Blood"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.1995.tb00322.x"},{"key":"e_1_2_9_17_1","first-page":"121","article-title":"Prophylaxis against infections with low\u2010dose intravenous immunoglobulins (IVIG) in chronic lymphocytic leukemia. 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