{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:29:56Z","timestamp":1789543796382,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:00:00Z","timestamp":1496361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Beijing health system high level health technical personnel training project","award":["2015-3-009"],"award-info":[{"award-number":["2015-3-009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The etiology of multiple myeloma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>) is unknown and it remains incurable. We sought to elucidate the mechanisms underlying mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s involvement in <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Public <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> and mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression datasets for <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> were collected from the Gene Expression Omnibus database. By integrated bioinformatics analysis, the expression signatures were identified and the mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> interaction network was constructed. The potential functions of target genes were then explored by functional enrichment analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Totally, 839 differentially expressed <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>s and six differentially expressed mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s were identified. The context of mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s\u2010mediated genes regulatory network consisted of 288 possible mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> target pairs. The hub mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> was hsa\u2010miR\u201092a, which can serve as the indicator for <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> disease status. Another mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>, hsa\u2010miR\u2010148a, could be useful for prognosis of <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>. Functional annotation revealed that the mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> targets may play important roles in viral infection and proteasome. Moreover, mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> targets may be involved in renal cell carcinoma and other nervous system disease such as Huntington's disease, Alzheimer's disease and Parkinson's disease, which may be subsequent complications of MM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Infections could be a leading cause for the morbidity of <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> patients. The crucial protein degradation machinery may be essential in the pathogenesis of <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12901","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T13:56:46Z","timestamp":1493819806000},"page":"178-185","source":"Crossref","is-referenced-by-count":7,"title":["Potential roles of microRNAs and their target genes in human multiple myeloma"],"prefix":"10.1111","volume":"99","author":[{"given":"Yong","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Orthopedics Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Beijing Friendship Hospital Capital Medical University  Beijing 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