{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:42:54Z","timestamp":1790876574896,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T00:00:00Z","timestamp":1498694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The role of PAI<\/jats:styled-content>\u20101 4G\/5G polymorphism in venous thrombosis has been contradictory. PAI<\/jats:styled-content>\u20101 4G\/4G genotype is associated with elevated levels of PAI<\/jats:styled-content>\u20101 resulting in a hypofibrinolytic state and a higher thrombotic risk.<\/jats:p><\/jats:sec>Objective<\/jats:title>In this study, the distribution of genotypes and frequency of alleles of the 4G\/5G polymorphism of PAI<\/jats:styled-content>\u20101 gene in Indian patients with different types of venous thrombosis was investigated for its role in development of thrombosis.<\/jats:p><\/jats:sec>Method<\/jats:title>A total of 87 portal vein thrombosis (PVT<\/jats:styled-content>), 71 Budd\u2010Chiari syndrome (BCS<\/jats:styled-content>), 156 cerebral vein thrombosis (CVT<\/jats:styled-content>), and 163 deep vein thrombosis (DVT<\/jats:styled-content>) patients were studied alongside 251 healthy controls for the PAI<\/jats:styled-content>\u20101 4G\/5G polymorphism by allele\u2010specific PCR<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Frequency of 4G\/4G genotype was higher in all groups in comparison with controls. 4G\/4G was associated with PVT<\/jats:styled-content> risk (OR<\/jats:styled-content>=2.51, 95% CI<\/jats:styled-content>=1.29\u20104.96, P<\/jats:italic>=.0075), BCS<\/jats:styled-content> risk (OR<\/jats:styled-content>=5.98, 95% CI<\/jats:styled-content>=2.68\u201013.42, P<\/jats:italic><<\/jats:bold>.0001), and DVT<\/jats:styled-content> risk (OR<\/jats:styled-content>=1.75, 95% CI<\/jats:styled-content>=0.98\u20103.02, P<\/jats:italic>=.0225). This is the first case\u2010control study from India establishing PAI<\/jats:styled-content>\u20101 4G\/4G as a strong risk factor for abdominal thrombosis (PVT<\/jats:styled-content> and BCS<\/jats:styled-content>). Statistically significant association was not found between 4G\/4G genotype and CVT<\/jats:styled-content> risk.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>PAI<\/jats:styled-content>\u20101 4G\/4G is a strong risk factor for venous thrombosis in Indian patients and should be included in laboratory testing panel of thrombophilia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12912","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T12:18:48Z","timestamp":1496233128000},"page":"249-254","source":"Crossref","is-referenced-by-count":25,"title":["Investigation of Plasminogen Activator Inhibitor\u20101 (PAI<\/scp>\u20101) 4G\/5G promoter polymorphism in Indian venous thrombosis patients: A case\u2010control study"],"prefix":"10.1111","volume":"99","author":[{"given":"Aniket","family":"Prabhudesai","sequence":"first","affiliation":[{"name":"Department of Thrombosis and Haemostasis KEM Hospital National Institute of Immunohaematology (ICMR) Parel Mumbai 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