{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:53:03Z","timestamp":1771051983342,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Small Program Grants, Center for Clinical and Translational Science, Mayo Clinic, Rochester MN","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>HLA<\/jats:styled-content>\u2010DPB<\/jats:styled-content>1 matching may impact allogeneic hematopoietic stem cell transplantation (ASCT<\/jats:styled-content>) outcomes; however, this locus is not in linkage disequilibrium with the remainder of the HLA<\/jats:styled-content> genes. After classifying HLA<\/jats:styled-content>\u2010DPB<\/jats:styled-content>1 mismatches based on T\u2010cell epitope, avoiding non\u2010permissive mismatches may impact survival. We tested this hypothesis at a single academic institution.<\/jats:p><\/jats:sec>Methods<\/jats:title>Retrospective HLA<\/jats:styled-content>\u2010DPB<\/jats:styled-content>1 genotyping was performed on 153 adult patients who underwent ASCT<\/jats:styled-content> and unrelated donors matched for HLA<\/jats:styled-content>\u2010A, B, C, DRB<\/jats:styled-content>1, and DQB<\/jats:styled-content>1 loci (10\/10). Using the ImMunoGeneTics\/HLA<\/jats:styled-content> T\u2010cell epitope matching algorithm, mismatch status was classified as permissive or non\u2010permissive.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 153 donor\u2010recipient pairs, 22 (14.4%) were HLA<\/jats:styled-content>\u2010DPB<\/jats:styled-content>1 matches, 64 (42.8%) permissive mismatches, and 67 (43.8%) non\u2010permissive mismatches. DPB<\/jats:styled-content>1 mismatch increased risk of chronic graft\u2010versus\u2010host disease (cGVHD<\/jats:styled-content>; RR<\/jats:styled-content> 2.89 [1.19\u20109.53], P<\/jats:italic>=.016) compared with DPB<\/jats:styled-content>1\u2010matched transplants, but there were no differences in overall mortality, risk of relapse, or acute GVHD<\/jats:styled-content> (aGVHD<\/jats:styled-content>). Combining matches and permissive mismatches and comparing to non\u2010permissive mismatches, there was no significant difference in overall survival or relapse; however, patients receiving non\u2010permissive mismatched transplants experienced greater risk of aGVHD<\/jats:styled-content> overall and severe aGVHD<\/jats:styled-content> (RR<\/jats:styled-content> 1.66 [1.13\u20102.44], P<\/jats:italic>=.010 and RR<\/jats:styled-content> 1.97 [1.10\u20103.59], P<\/jats:italic>=.024, respectively).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In this single\u2010center study, HLA<\/jats:styled-content>\u2010DPB<\/jats:styled-content>1 matching influenced outcomes of patients undergoing ASCT<\/jats:styled-content> for hematologic malignancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12916","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T15:42:44Z","timestamp":1497973364000},"page":"275-282","source":"Crossref","is-referenced-by-count":12,"title":["Clinical outcomes of HLA<\/scp>\u2010DPB<\/scp>1 mismatches in 10\/10 HLA<\/scp>\u2010matched unrelated donor\u2010recipient pairs undergoing allogeneic stem cell transplant"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2590-7218","authenticated-orcid":false,"given":"Ann M.","family":"Moyer","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahrukh K.","family":"Hashmi","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia M.","family":"Kroning","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter K.","family":"Kremers","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R.","family":"De Goey","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mrinal","family":"Patnaik","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Litzow","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis A.","family":"Gastineau","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA"},{"name":"Division of Hematology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Hogan","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eapen K.","family":"Jacob","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin D.","family":"Kreuter","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie 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