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Higher d\u2010<jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content>s values were found in female (<jats:italic>P<\/jats:italic>=.0003), in patients with unmutated Ig<jats:styled-content style=\"fixed-case\">VH<\/jats:styled-content> (<jats:italic>P<\/jats:italic>=.04), unfavourable cytogenetics (<jats:italic>P<\/jats:italic>=.002) and more advanced clinical stage (<jats:italic>P<\/jats:italic>=.002). Higher <jats:styled-content style=\"fixed-case\">BAP<\/jats:styled-content> test values were found in patients expressing <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>49d (<jats:italic>P<\/jats:italic>=.01) and with more advanced clinical stage (<jats:italic>P<\/jats:italic>=.004). At a median follow\u2010up of 48\u00a0months, <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> patients with d\u2010<jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content>s \u2265418 <jats:styled-content style=\"fixed-case\">CARR<\/jats:styled-content> U were found to have a shorter time to first treatment (<jats:styled-content style=\"fixed-case\">TFT<\/jats:styled-content>) (<jats:italic>P<\/jats:italic>=.0002), and a reduced survival (<jats:italic>P<\/jats:italic>=.006) than others. <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">BAP<\/jats:styled-content> test values \u22652155\u00a0\u03bcmol\/L had a shorter <jats:styled-content style=\"fixed-case\">TFT<\/jats:styled-content> (<jats:italic>P<\/jats:italic>=.008) and a shorter survival (<jats:italic>P<\/jats:italic>=.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> can affect <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> patients by concomitantly increasing reactive oxygen metabolites production and decreasing antioxidant defences.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12918","type":"journal-article","created":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T14:28:40Z","timestamp":1498314520000},"page":"306-314","source":"Crossref","is-referenced-by-count":12,"title":["Prognostic relevance of oxidative stress measurement in chronic lymphocytic leukaemia"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3807-7287","authenticated-orcid":false,"given":"Giovanni","family":"D'Arena","sequence":"first","affiliation":[{"name":"Hematology and Stem Cell Transplantation Unit IRCCS Centro di Riferimento Oncologico della Basilicata  Rionero in Vulture Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candida","family":"Vitale","sequence":"additional","affiliation":[{"name":"Division of Hematology AOU Citt\u00e0 della Salute e della Scienza di Torino University of Torino  Torino Italy"},{"name":"Department of Molecular Biotechnology and Health Sciences University of Torino  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Perbellini","sequence":"additional","affiliation":[{"name":"Hematology Unit, \u201cS. 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