{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:25:56Z","timestamp":1790072756456,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the prognostic impact of hypercalcemia in newly diagnosed patients with symptomatic multiple myeloma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>), especially after the incorporation of new agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>we analyzed the outcomes of newly diagnosed patients with symptomatic myeloma included in the database of the Greek Myeloma Study Group for the prognostic effect of the presence of hypercalcemia (defined as corrected serum calcium \u226511\u00a0mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>) at diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 2129 consecutive patients with symptomatic <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>, 19.5% presented with hypercalcemia at the time of diagnosis. The presence of hypercalcemia was associated with anemia, thrombocytopenia, lower estimated glomerular filtration rate (<jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>), advanced <jats:styled-content style=\"fixed-case\">ISS<\/jats:styled-content> stage, and presence of lytic lesions. Hypercalcemia was more common in patients with high\u2010risk cytogenetics and was associated with inferior survival across different time periods, age groups, and primary treatments. Hypercalcemia was also associated with a twofold increase in the risk of early death. In patients without available <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>, hypercalcemia could substitute for the presence of high\u2010risk cytogenetics and identify patients with worse prognosis along with <jats:styled-content style=\"fixed-case\">ISS<\/jats:styled-content> stage and elevated serum <jats:styled-content style=\"fixed-case\">LDH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hypercalcemia remains a poor prognostic feature in the era of novel agents despite the improvement in the outcomes of patients who present with elevated calcium.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12923","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T17:52:37Z","timestamp":1499190757000},"page":"409-414","source":"Crossref","is-referenced-by-count":47,"title":["Hypercalcemia remains an adverse prognostic factor for newly diagnosed multiple myeloma patients in the era of novel antimyeloma therapies"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7153-6556","authenticated-orcid":false,"given":"Flora","family":"Zagouri","sequence":"first","affiliation":[{"name":"Department of Clinical Therapeutics, Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstathios","family":"Kastritis","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Zomas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Attikon Hospital  Haidari Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Terpos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini","family":"Katodritou","sequence":"additional","affiliation":[{"name":"Department of Hematology \u201cTheageneion\u201d Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argiris","family":"Symeonidis","sequence":"additional","affiliation":[{"name":"Hematology Division Department of Internal Medicine University of Patras Medical School  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sosana","family":"Delimpasi","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation and Lymphoma Unit \u201cEvangelismos\u201d Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Pouli","sequence":"additional","affiliation":[{"name":"Department of Hematology \u201cAghios Savvas\u201d Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoros P.","family":"Vassilakopoulos","sequence":"additional","affiliation":[{"name":"Department of Hematology and BMT Unit National and Kapodistrian University of Athens Laikon General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eurydiki","family":"Michalis","sequence":"additional","affiliation":[{"name":"Department of Hematology \u201cG. Gennimatas\u201d Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavroula","family":"Giannouli","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zafiris","family":"Kartasis","sequence":"additional","affiliation":[{"name":"Chalkis General Hospital  Chalkis Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Christoforidou","sequence":"additional","affiliation":[{"name":"Department of Hematology Democritus University of Thrace Faculty of Medicine  Alexandroupolis Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiriaki","family":"Kokoviadou","sequence":"additional","affiliation":[{"name":"Department of Hematology \u201cPapageorgiou\u201d Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftheria","family":"Hatzimichael","sequence":"additional","affiliation":[{"name":"Department of Hematology University of Ioannina  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Gika","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Megalakaki","sequence":"additional","affiliation":[{"name":"Department of Hematology \u201cMetaxa\u201d Hospital  Piraeus Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Papaioannou","sequence":"additional","affiliation":[{"name":"AHEPA University General Hospital of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Christine","family":"Kyrtsonis","sequence":"additional","affiliation":[{"name":"First Department of Propaedeutic and Internal Medicine National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostas","family":"Konstantopoulos","sequence":"additional","affiliation":[{"name":"Department of Hematology and BMT Unit National and Kapodistrian University of Athens Laikon General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meletios A.","family":"Dimopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Greek Myeloma Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24402"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2168"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.4065\/78.1.21"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197509)36:3<842::AID-CNCR2820360303>3.0.CO;2-U"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70442-5"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.09.36"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2007.09.002"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.242"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.2267"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2016.1226166"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2000.90221.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.749"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24129"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/10245332.2015.1101969"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.2086"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2645-y"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt483"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12923","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:25:09Z","timestamp":1695486309000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,26]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/ejh.12923"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12923","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,26]]}}}