{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T20:47:29Z","timestamp":1775249249775,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to evaluate the clinical and laboratory outcomes of a group of patients with \u03b2\u2010thalassaemia major or intermedia treated with thalidomide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical and laboratory data were obtained by analysing medical records of \u03b2\u2010thalassaemia patients. Using the self\u2010control method, the levels of haemoglobin (Hb), foetal haemoglobin (HbF), white blood cells (<jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>) and platelets were detected before and after the treatment, and adverse reactions were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from the medical records of 9 patients were analysed. The median haemoglobin levels of these patients increased from 5.13\u00a0\u00b1\u00a02.15\u00a0g\/dL before treatment to 10.38\u00a0\u00b1\u00a01.19\u00a0g\/dL after treatment. The average spleen size decreased from a pretreatment length of 8.19\u00a0\u00b1\u00a03.10 to 5.49\u00a0\u00b1\u00a01.80\u00a0cm below the costal margin after treatment. The mean HbF levels increased from a pretreatment value of 35.67%\u00a0\u00b1\u00a026.82% to 75.67%\u00a0\u00b1\u00a014.64% after treatment in the 9 patients for whom these measurements were available. All patients no longer needed transfusions by 1\u00a0month after treatment. No serious adverse reactions were observed in any of the thalidomide\u2010treated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, thalidomide showed an outstanding effect on \u03b2\u2010thalassaemia patients who required frequent red\u2010cell transfusions. Thalidomide increased haemoglobin levels without causing serious adverse reactions, but the long\u2010term curative outcomes and other side effects should be observed continuously.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12955","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T15:19:46Z","timestamp":1504019986000},"page":"437-441","source":"Crossref","is-referenced-by-count":28,"title":["Thalidomide induces haematologic responses in patients with \u03b2\u2010thalassaemia"],"prefix":"10.1111","volume":"99","author":[{"given":"Jiangming","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Haematology Wuzhou Gongren Hospital  Wuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2120-5860","authenticated-orcid":false,"given":"Weijian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Haematology Zhuhai Hospital Jinan University  Zhuhai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Haematology Wuzhou Gongren Hospital  Wuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengdi","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Haematology Wuzhou Gongren Hospital  Wuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Haematology Wuzhou Gongren Hospital  Wuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Haematology Wuzhou Gongren Hospital  Wuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3536(05)80071-X"},{"key":"e_1_2_6_3_1","first-page":"14","article-title":"Hemoglobinopathies","volume":"2003","author":"Atweh GF","year":"2003","journal-title":"ASH Education Program Book"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2014.01.003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI32322"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-01-065201"},{"key":"e_1_2_6_7_1","first-page":"63","article-title":"Optimal response to thalidomide in a patient with thalassaemia major resistant to conventional therapy","volume":"8","author":"Masera N","year":"2010","journal-title":"Blood Transfus"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2008.03.001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04065.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-319137"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2015.08.001"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12955","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:25:05Z","timestamp":1695486305000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,27]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/ejh.12955"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12955","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,27]]}}}