{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T05:12:21Z","timestamp":1774501941671,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T00:00:00Z","timestamp":1507593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>In patients with Ewing sarcoma and some distinct subgroups of soft tissue sarcoma (STS<\/jats:styled-content>), a quantitatively sufficient autologous peripheral blood stem cell (PBSC<\/jats:styled-content>) collection for stem cell support might facilitate treatment continuation, dose\u2010intensification, and high\u2010dose chemotherapy. Here, we provide a detailed evaluation of PBSC<\/jats:styled-content> collection upon vincristine, ifosfamide, doxorubicin, and etoposide (VIDE<\/jats:styled-content>) chemomobilization.<\/jats:p><\/jats:sec>Methods<\/jats:title>Mobilization and collection parameters of 42 sarcoma patients (Ewing sarcoma n\u00a0=\u00a035, other STS<\/jats:styled-content> n\u00a0=\u00a07) were analyzed retrospectively. Data were evaluated with regard to the number of previous VIDE<\/jats:styled-content> therapy cycles.<\/jats:p><\/jats:sec>Results<\/jats:title>All patients reached the collection goal of \u22652.0\u00a0\u00d7\u00a0106<\/jats:sup> CD<\/jats:styled-content>34+<\/jats:sup> cells\/kg body weight (bw) upon VIDE<\/jats:styled-content>\/G\u2010CSF<\/jats:styled-content> mobilization, in the majority of cases with one single leukapheresis (LP<\/jats:styled-content>) session (n\u00a0=\u00a029, 69%). No significant differences were identified with regard to mobilization and collection variables or the number of previous induction VIDE<\/jats:styled-content> therapy cycles. However, upon 5 cycles of VIDE<\/jats:styled-content>, we found the highest relative proportion of patients who required two or three LP<\/jats:styled-content> sessions.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our data demonstrate the feasibility of successful PBSC<\/jats:styled-content> collection upon VIDE<\/jats:styled-content> chemomobilization even after up to five cycles of induction therapy, while at the same time the increasing risk of bone marrow exhaustion with every consecutive cycle is outlined.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12960","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T11:32:27Z","timestamp":1504870347000},"page":"459-464","source":"Crossref","is-referenced-by-count":5,"title":["Successful collection of peripheral blood stem cells upon VIDE<\/scp> chemomobilization in sarcoma patients"],"prefix":"10.1111","volume":"99","author":[{"given":"Katharina","family":"Kriegsmann","sequence":"first","affiliation":[{"name":"Department of Medicine V Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8869-1421","authenticated-orcid":false,"given":"Christoph","family":"Heilig","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Cremer","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Novotny","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Kriegsmann","sequence":"additional","affiliation":[{"name":"Institute of Pathology Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Bruckner","sequence":"additional","affiliation":[{"name":"Institute of Medical Biometry und Informatics Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"M\u00fcller\u2010Tidow","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerlinde","family":"Egerer","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9482-2870","authenticated-orcid":false,"given":"Patrick","family":"Wuchter","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University Heidelberg Germany"},{"name":"Institute of Transfusion Medicine and Immunology Medical Faculty Mannheim Heidelberg University Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,10]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"3281","article-title":"Tandem high\u2010dose chemotherapy followed by autologous transplantation in patients with locally advanced or metastatic sarcoma","volume":"29","author":"Lashkari A","year":"2009","journal-title":"Anticancer Res"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000156921.28880.e1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700992"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.8.1482"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-013-1298-8"},{"key":"e_1_2_7_7_1","unstructured":"Study in Localized and Disseminated Ewing Sarcoma (EWING2008). 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