{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:15:39Z","timestamp":1791396939169,"version":"4.3.3"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T00:00:00Z","timestamp":1508457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>Although commonly associated with high\u2010grade myelodysplastic syndrome (MDS<\/jats:styled-content>) and MDS<\/jats:styled-content> with a complex karyotype, TP53<\/jats:italic> mutations also occur in low\u2010grade MDS<\/jats:styled-content> and MDS<\/jats:styled-content> with a non\u2010complex karyotype. In latter cases, their clinicopathological features and the characteristics of TP53<\/jats:italic> mutations remain poorly characterized.<\/jats:p><\/jats:sec>Methods<\/jats:title>176 MDS<\/jats:styled-content> cases with TP53<\/jats:italic> mutations were stratified and characterized based on their karyotype and histologic subtype.<\/jats:p><\/jats:sec>Results<\/jats:title>Among 176 cases, 17% had a non\u2010complex karyotype and 24% were low\u2010grade MDS<\/jats:styled-content>. TP53<\/jats:italic> mutations often occurred in DNA<\/jats:styled-content>\u2010binding domains and the majority of cases had only one mutation, irrespective of their karyotype and MDS<\/jats:styled-content> subtype. The variant allele frequency (VAF<\/jats:styled-content>), however, was associated with karyotype complexity and the types of MDS<\/jats:styled-content> with a lower VAF<\/jats:styled-content> found in cases with a non\u2010complex karyotype and low\u2010grade MDS<\/jats:styled-content>. A low (<20%) VAF<\/jats:styled-content> was associated with a better survival, as well as low\u2010grade subtype.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In low\u2010grade MDS<\/jats:styled-content> and MDS<\/jats:styled-content> with a non\u2010complex karyotype, TP<\/jats:styled-content>53<\/jats:italic> mutations showed a lower VAF<\/jats:styled-content>. Patients with a lower VAF<\/jats:styled-content> had a better survival. TP<\/jats:styled-content>53<\/jats:italic> mutations are not the only prognostic factor in MDS<\/jats:styled-content> patients with TP<\/jats:styled-content>53<\/jats:italic> mutations as the VAF<\/jats:styled-content>, blast counts and history of prior therapy also play important roles in prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12971","type":"journal-article","created":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T14:43:44Z","timestamp":1505832224000},"page":"536-543","source":"Crossref","is-referenced-by-count":21,"title":["Characterization of TP<\/scp>53<\/i> mutations in low\u2010grade myelodysplastic syndromes and myelodysplastic syndromes with a non\u2010complex karyotype"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6821-4556","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Routbort","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenya","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Young","family":"Ok","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyur P.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naval","family":"Daver","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Garcia\u2010Manero","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa A.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3711"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947601911408889"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.190678.112"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12203"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-09-381665"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.304"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.74"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-015-0139-z"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.076729"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9200"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2014.03.012"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.8576"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15099"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1605949"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1997.334"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201776"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.10.019"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408617"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13968"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.130"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.6.1909"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.263"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.6.2079"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-420489"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1013343"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.7379"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-06-582809"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.298"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12971","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T17:14:22Z","timestamp":1696698862000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,20]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/ejh.12971"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12971","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,20]]}}}