{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T05:21:52Z","timestamp":1769923312629,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T00:00:00Z","timestamp":1508112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to prospectively explore the detailed longitudinal development of platelet increments in patients with chemotherapy\u2010induced bone marrow aplasia during the first 24\u00a0hours after platelet transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients admitted to the Haematology department during 7\u00a0months, and fulfilled inclusion criteria were divided into 4 groups: Group 1, patients with acute leukaemia; Group 2, patients after autologous stem cell transplantation (<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>); Group 3, patients after allogeneic <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>; and Group 4, patients given platelet transfusion prior to intervention. We used frequent blood sampling within 24\u00a0hours after platelet transfusion to investigate the kinetics of platelet counts following transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Conclusions<\/jats:title><jats:p>Fifty\u2010four platelet transfusion occasions in patients with chemotherapy\u2010induced bone marrow aplasia were included. The decrease in corrected count increment (<jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>) 1\u201024\u00a0hours after platelet transfusions in all groups could be described as linear functions. For patients in the aggregated Groups 1\u20103, the decline was 2.0%\u00a0\u00b1\u00a00.6% (mean\u00a0\u00b1\u00a0standard deviation) per hour. For patients in Group 4, the decline of <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content> was 2.8%\u00a0\u00b1\u00a01.2% per hour. We found no differences between the groups, either in the rate of platelet elimination from the bloodstream or in the mean <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>, in the first 24\u00a0hours post\u2010transfusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12974","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T04:02:51Z","timestamp":1506484971000},"page":"559-568","source":"Crossref","is-referenced-by-count":9,"title":["Linear decline of corrected platelet count increment within 24\u00a0hours after platelet transfusion in haematological patients: A prospective observational study"],"prefix":"10.1111","volume":"99","author":[{"given":"Sigurdur","family":"Benediktsson","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund University  Lund Sweden"},{"name":"Department of Intensive and Perioperative Care Sk\u00e5ne University Hospital in Lund  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1782-4423","authenticated-orcid":false,"given":"Vladimir","family":"Lazarevic","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Lund Sweden"},{"name":"Department of Haematology, Oncology and Radiation Physics Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Lund Sweden"},{"name":"Department of Haematology, Oncology and Radiation Physics Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Kjeldsen\u2010Kragh","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Lund Sweden"},{"name":"Department of Clinical Immunology and Transfusion Medicine 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