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Historically, Emp was the first identified cell attachment molecule and is expressed in both erythroblasts and macrophages and mediates their attachments to form erythroblastic islands. The absence of Emp erythroblasts shows defects in differentiation and enucleation. Emp\u2010deficient macrophages display immature morphology characterized by small sizes, round shapes, and the lack of cytoplasmic projections. Although the primary sequence of Emp has already been determined and its role in both erythroid and macrophage development is well established, there are major gaps in the understanding of its function at the molecular level. Recent studies had implicated its importance in actin cytoskeleton remodeling and cell migration, but the molecular mechanisms are still enigmatic. Previous studies have also demonstrated that downregulation of Emp affects the expression of mitogen\u2010associated protein kinase 1 (<jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content>1) and thymoma viral protooncogene (<jats:styled-content style=\"fixed-case\">AKT<\/jats:styled-content>\u20101) resulting in abnormal cell motility. In this review, we summarize the proposed function of Emp based on previous studies, present scenarios, and its plausible future in translational research.<\/jats:p>","DOI":"10.1111\/ejh.12983","type":"journal-article","created":{"date-parts":[[2017,10,15]],"date-time":"2017-10-15T14:16:39Z","timestamp":1508076999000},"page":"3-9","source":"Crossref","is-referenced-by-count":18,"title":["Erythroblast macrophage protein (Emp): Past, present, and future"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0957-0603","authenticated-orcid":false,"given":"Gulnaz T.","family":"Javan","sequence":"first","affiliation":[{"name":"Physical Sciences Department Forensic Science Program Alabama State University Montgomery AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandeep","family":"Salhotra","sequence":"additional","affiliation":[{"name":"Department of Hematology and HCT City of Hope Duarte CA 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