{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:53:35Z","timestamp":1761490415284,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T00:00:00Z","timestamp":1511395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Invasive Aspergillosis (<jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>) is a serious problem among hematological patients and it is associated with high mortality. This situation can worsen at times of hospital construction, however there are several preventive measures available. This work aims to define the cost\u2010effectiveness of some of these interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>A decision tree model was used, it was divided into four arms according to each 1 of the interventions performed. A cost\u2010effectiveness incremental analysis comparing environmental control measures, high efficiency particulate absorption (<jats:styled-content style=\"fixed-case\">HEPA<\/jats:styled-content>) filter installation and prophylaxis with posaconazole was done. Probabilistic and deterministic sensitivity analyses were also carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 86 patients with 175 hospitalization episodes, the incidence of <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> with environmental protection measures, antifungal prophylaxis and hospitalization in rooms with <jats:styled-content style=\"fixed-case\">HEPA<\/jats:styled-content> filters was 14.4%, 6.3% and 0%, respectively. An Incremental Cost Effectiveness Ratio analysis was performed and it was found that <jats:styled-content style=\"fixed-case\">HEPA<\/jats:styled-content> filtered rooms and environmental protection measures are cost saving interventions when compared with posaconazole prophylaxis (\u2212$2665 vs \u2212$4073 vs $42\u00a0531 <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> dollars, respectively) for <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> episode prevented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The isolation of inpatients with acute leukemia during hospital construction periods in <jats:styled-content style=\"fixed-case\">HEPA<\/jats:styled-content> filtered rooms could reduce the incidence of <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> and might be a cost\u2010effective prevention strategy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12991","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T07:53:09Z","timestamp":1509954789000},"page":"140-146","source":"Crossref","is-referenced-by-count":10,"title":["Cost\u2013effectiveness analysis of interventions for prevention of invasive aspergillosis among leukemia patients during hospital construction activities"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5574-6091","authenticated-orcid":false,"given":"Juan F.","family":"Combariza","sequence":"first","affiliation":[{"name":"Hospital Pablo Tob\u00f3n Uribe  Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis F.","family":"Toro","sequence":"additional","affiliation":[{"name":"Universidad CES  Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Orozco","sequence":"additional","affiliation":[{"name":"Universidad CES  Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Arango","sequence":"additional","affiliation":[{"name":"Hospital Pablo Tob\u00f3n Uribe  Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,23]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1068","article-title":"The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM\u20102004 study","volume":"91","author":"Pagano L","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2012.09.004"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2008.01727.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2006.02.014"},{"key":"e_1_2_5_6_1","first-page":"1","article-title":"Guidelines for environmental infection control in health\u2010care facilities. 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