{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:37:35Z","timestamp":1791956255970,"version":"4.3.4"},"reference-count":6,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,17]],"date-time":"2017-12-17T00:00:00Z","timestamp":1513468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001663","name":"Volkswagenstiftung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Cryptosporidium<\/jats:italic> infection is a rare cause of enterocolitis. In immunocompromised patients, cryptosporidiosis may lead to debilitating and life\u2010threatening diarrhea and malabsorption, occasionally with multi\u2010organ involvement. Allogeneic hematopoietic stem cell transplantation (allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) requires long\u2010term immunosuppressive therapy, while cellular immunity is usually compromised due to intensive conditioning chemotherapy. Diarrhea in patients who underwent allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> may be a sign of an infection, but can also be the result of intestinal graft\u2010versus\u2010host disease (Gv<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>). Here, we describe the case of a patient who developed severe diarrhea following allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> for relapsed T\u2010lymphoblastic lymphoma. Initially, Gv<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> was suspected and treatment was initiated accordingly. However, a colon biopsy showed signs of cryptosporide oocysts alongside only low\u2010grade Gv<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>. Following molecular confirmation of the diagnosis of cryptosporidiosis, an intensive treatment regimen was started. Despite the severe clinical course, the patient recovered and was discharged with only residual symptoms.<\/jats:p>","DOI":"10.1111\/ejh.12998","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T14:38:39Z","timestamp":1510756719000},"page":"383-385","source":"Crossref","is-referenced-by-count":7,"title":["Case Report: A <i>Cryptosporidium<\/i> infection in a patient with relapsed T\u2010lymphoblastic lymphoma undergoing allogeneic stem cell transplantation"],"prefix":"10.1111","volume":"100","author":[{"given":"Joanna","family":"Schiller","sequence":"first","affiliation":[{"name":"Clinic I of Internal Medicine University Hospital of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Klein","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Hospital of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Engels","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Hospital of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"B\u00fcttner","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Hospital of Cologne  Cologne Germany"},{"name":"Center for Molecular Medicine Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Rybniker","sequence":"additional","affiliation":[{"name":"Clinic I of Internal Medicine University Hospital of Cologne  Cologne Germany"},{"name":"Center for Molecular Medicine Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"F\u00e4tkenheuer","sequence":"additional","affiliation":[{"name":"Clinic I of Internal Medicine University Hospital of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Scheid","sequence":"additional","affiliation":[{"name":"Clinic I of Internal Medicine University Hospital of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Wybranski","sequence":"additional","affiliation":[{"name":"Institute of Radiology University Hospital of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Quaas","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Hospital of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Christian","family":"Reinhardt","sequence":"additional","affiliation":[{"name":"Clinic I of Internal Medicine University Hospital of Cologne  Cologne Germany"},{"name":"Center for Molecular Medicine Cologne  Cologne Germany"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD) University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5514-8342","authenticated-orcid":false,"given":"Ruth","family":"Fl\u00fcmann","sequence":"additional","affiliation":[{"name":"Clinic I of Internal Medicine University Hospital of Cologne  Cologne Germany"},{"name":"Center for Molecular Medicine Cologne  Cologne Germany"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD) University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000833"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"pii: 20348","DOI":"10.2807\/ese.18.02.20348-en","article-title":"Simultaneous increase of Cryptosporidium infections in the Netherlands, the United Kingdom and Germany in late summer season, 2012","volume":"18","author":"Fournet N","year":"2013","journal-title":"Euro Surveill"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.200"},{"key":"e_1_2_5_5_1","article-title":"Prevention and treatment of cryptosporidiosis in immunocompromised patients","volume":"004932","author":"Abubakar I","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_6_1","first-page":"851","article-title":"Treatment of adult acute lymphoblastic leukemia (ALL) with a focus on emerging investigational and targeted therapies","volume":"26","author":"Mathisen MS","year":"2012","journal-title":"Oncology (Williston Park)"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.072264"}],"container-title":["European Journal of 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