{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:44:56Z","timestamp":1784547896728,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T00:00:00Z","timestamp":1515628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>Second allogeneic hematopoietic cell transplantation (HCT<\/jats:styled-content>) may be indicated following relapse or graft failure following first HCT<\/jats:styled-content>. Our retrospective single\u2010center study sought to investigate parameters that influence post\u2010second allogeneic HCT<\/jats:styled-content> survival.<\/jats:p><\/jats:sec>Method<\/jats:title>We investigated 92 patients who underwent second allogeneic HCT<\/jats:styled-content> between 1980 and 2016 for relapse or graft failure following first HCT<\/jats:styled-content>. Median age at second HCT<\/jats:styled-content> was 41 years (range 16\u201068), performed for relapse in 59 patients (64%) and for graft failure in 33 patients (36%).<\/jats:p><\/jats:sec>Results<\/jats:title>On univariate analysis, 3\u2010year OS<\/jats:styled-content> of the entire cohort was 35% (95% CI<\/jats:styled-content>=25\u201045). Eastern Cooperative Oncology Group (ECOG) score (3\u2010year OS<\/jats:styled-content> 48% for ECOG<\/jats:styled-content> 0\u20101, 18% for ECOG<\/jats:styled-content> 2\u20103, P<\/jats:italic>=.0006), second HCT<\/jats:styled-content> indication (3\u2010year OS<\/jats:styled-content> 43% for relapse, 20% for graft failure, P<\/jats:italic>=.02), time from first HCT<\/jats:styled-content> to relapse\/graft failure (3\u2010year OS<\/jats:styled-content> for <12months 21%, for \u226512months 46%, P<\/jats:italic>=.009), and conditioning intensity (3\u2010year OS<\/jats:styled-content> for MA<\/jats:styled-content> 42% vs other regimens 23%, P<\/jats:italic>=.08) significantly influenced OS<\/jats:styled-content>. Multivariable analysis confirmed ECOG<\/jats:styled-content> score (HR<\/jats:styled-content>=2.15 for ECOG<\/jats:styled-content> 2\u20103, 95% CI<\/jats:styled-content>=1.32\u20103.51, P<\/jats:italic>=.002) and second HCT<\/jats:styled-content> indication (HR<\/jats:styled-content>=1.67 for graft failure, 95% CI<\/jats:styled-content>=1.02\u20102.75, P<\/jats:italic>=.04) to independently influence survival.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Second HCT<\/jats:styled-content> may offer long\u2010term survival particularly to patients with good performance status who relapse post\u2010first HCT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13015","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T15:00:21Z","timestamp":1513263621000},"page":"308-314","source":"Crossref","is-referenced-by-count":16,"title":["Outcome following second allogeneic hematopoietic cell transplantation: A single\u2010center experience"],"prefix":"10.1111","volume":"100","author":[{"given":"Hassan A.","family":"Aljasem","sequence":"first","affiliation":[{"name":"Allogeneic Blood and Marrow Transplant Program Princess Margaret Cancer Centre University Health Network University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans A.","family":"Messner","sequence":"additional","affiliation":[{"name":"Allogeneic Blood and Marrow Transplant Program Princess Margaret Cancer Centre University Health Network University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey H.","family":"Lipton","sequence":"additional","affiliation":[{"name":"Allogeneic Blood and Marrow Transplant Program Princess Margaret Cancer Centre University Health Network University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis Dong Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Allogeneic Blood and Marrow Transplant Program Princess Margaret Cancer Centre University Health Network University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auro","family":"Viswabandya","sequence":"additional","affiliation":[{"name":"Allogeneic Blood and Marrow Transplant Program Princess Margaret Cancer Centre University Health Network University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santhosh","family":"Thyagu","sequence":"additional","affiliation":[{"name":"Allogeneic Blood and Marrow Transplant Program Princess Margaret Cancer Centre University Health Network University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uday","family":"Deotare","sequence":"additional","affiliation":[{"name":"Allogeneic Blood and Marrow Transplant Program Princess Margaret Cancer Centre University Health Network University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2956-0848","authenticated-orcid":false,"given":"Fotios V.","family":"Michelis","sequence":"additional","affiliation":[{"name":"Allogeneic Blood and Marrow Transplant Program Princess Margaret Cancer Centre University Health Network University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2013.09.011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.741230"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704645"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.08.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.12.713"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.10.006"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2016.10.011"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400585"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3283257a87"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.239"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705882"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.05.005"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.02.013"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24111"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197410000-00001"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90380-0"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.07.004"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704379"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.011809"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2308"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.11.007"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.01.009"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.d01-1483.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.08.020"}],"container-title":["European 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