{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:18:43Z","timestamp":1790245123293,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006556","name":"Centre Hospitalier Universitaire de Toulouse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006556","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the benefits and harms to initiate corticosteroids with intravenous methylprednisolone at a conventional dose (1\u00a0mg\/kg\/d) to treat adults with immune thrombocytopenia (<jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Population stemmed from the prospective multicenter <jats:styled-content style=\"fixed-case\">CARMEN<\/jats:styled-content> registry and included newly diagnosed hospitalized <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> adults with platelet counts&lt;30\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L. We compared the patients treated with conventional\u2010dose methylprednisolone (<jats:styled-content style=\"fixed-case\">CDMP<\/jats:styled-content>) before continuing with oral prednisone to patients treated with just conventional\u2010dose oral prednisone (<jats:styled-content style=\"fixed-case\">CDOP<\/jats:styled-content>). The primary outcome was the time until response. Secondary outcomes were time until complete response, response rate, complete response rate, duration of hospital stay, and occurrence of adverse drug reactions. Analyzes were adjusted for propensity score and for exposure to intravenous immunoglobulin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the included 87 patients, the median time to response was 3\u00a0days in the <jats:styled-content style=\"fixed-case\">CDMP<\/jats:styled-content> group vs 4 in the <jats:styled-content style=\"fixed-case\">CDOP<\/jats:styled-content> group (adjusted hazard ratio [<jats:styled-content style=\"fixed-case\">aHR<\/jats:styled-content>]: 1.35; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.76\u20102.41). The <jats:styled-content style=\"fixed-case\">CDMP<\/jats:styled-content> group had an earlier complete response (<jats:styled-content style=\"fixed-case\">aHR<\/jats:styled-content>: 2.29; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.20\u20104.36). There was no difference between the groups regarding other secondary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Initiating methylprednisolone at a conventional dose provided no significant benefit compared to giving oral prednisone only to adults with <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13032","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T14:02:45Z","timestamp":1516716165000},"page":"412-418","source":"Crossref","is-referenced-by-count":3,"title":["Pretreatment with standard\u2010dose intravenous methylprednisolone does not improve outcomes in newly diagnosed immune thrombocytopenia (<scp>ITP<\/scp>)"],"prefix":"10.1111","volume":"100","author":[{"given":"Ana\u00efs","family":"Essilini","sequence":"first","affiliation":[{"name":"CIC 1436 Centre Hospitalier Universitaire de Toulouse  Toulouse France"},{"name":"UMR1027 Inserm 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