{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:05:07Z","timestamp":1790665507455,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>We aimed at investigating the relationship between classical Hodgkin lymphoma (cHL<\/jats:styled-content>), primary mediastinal large B\u2010cell lymphoma (PMBL<\/jats:styled-content>), and gray zone lymphoma (GZL<\/jats:styled-content>) with intermediate characteristics between cHL<\/jats:styled-content> and PMBL<\/jats:styled-content>, from the perspective of the aberration in programed cell death 1 and the programed death ligands (PDL<\/jats:styled-content>s) network.<\/jats:p><\/jats:sec>Methods<\/jats:title>We explored the expression levels of PDL<\/jats:styled-content>s and chromosomal anomalies in 67 cases: 34 cases with cHL<\/jats:styled-content>, 20 with PMBL<\/jats:styled-content>, and 13 with GZL<\/jats:styled-content>, using immunohistochemical analyses and Fluorescence In Situ Hybridization (FISH<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Twenty\u2010one cHL<\/jats:styled-content> (62%), 3 PMBL<\/jats:styled-content> (15%), and 6 GZL<\/jats:styled-content> (46%) cases showed staining to PD<\/jats:styled-content>\u2010L1 antibodies in more than 70% of tumor cells. Two cHL<\/jats:styled-content> (6%), 10 PMBL<\/jats:styled-content> (50%), and 3 GZL<\/jats:styled-content> (23%) cases were not stained by PD<\/jats:styled-content>\u2010L1 antibodies. Patients over 40\u00a0years old manifest more frequent expression of PD<\/jats:styled-content>\u2010L1 in cHL<\/jats:styled-content>. Proportion of tumors stained by PD<\/jats:styled-content>\u2010L2 antibody was increased in PMBL<\/jats:styled-content>. FISH<\/jats:styled-content> analyses with a PD<\/jats:styled-content>\u2010L1\/PD<\/jats:styled-content>\u2010L2 probe detected 5 amplification, 1 gain, and 7 polysomy cases in cHL<\/jats:styled-content>, 1 amplification and 1 polysomy case in GZL<\/jats:styled-content>, and amplification in 1 PMBL<\/jats:styled-content> case.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We identified increased staining of PD<\/jats:styled-content>\u2010L1 in cHL<\/jats:styled-content> and that of PD<\/jats:styled-content>\u2010L2 in PMBL<\/jats:styled-content>. GZL<\/jats:styled-content> had a pattern similar to that of cHL<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13033","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T20:03:45Z","timestamp":1517256225000},"page":"511-517","source":"Crossref","is-referenced-by-count":43,"title":["Expression pattern of PD<\/scp>\u2010L1 and PD<\/scp>\u2010L2 in classical Hodgkin lymphoma, primary mediastinal large B\u2010cell lymphoma, and gray zone lymphoma"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3290-2848","authenticated-orcid":false,"given":"Yosuke","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Chuo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko Miyagi","family":"Maeshima","sequence":"additional","affiliation":[{"name":"Department of Pathology and Clinical Laboratory National Cancer Center Hospital Chuo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Nomoto","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Chuo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Makita","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Chuo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suguru","family":"Fukuhara","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Chuo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Munakata","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Chuo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Chuo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensei","family":"Tobinai","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Chuo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2378-7865","authenticated-orcid":false,"given":"Yukio","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Chuo\u2010ku Tokyo Japan"},{"name":"Department of Hematology International University of Health and Welfare Mita Hospital Minato\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214561"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199211193272102"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031074"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-1841"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-326538"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412082"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507643"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411087"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-535443"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000297"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.66.4482"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09754"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.10.0917"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-016-1883-9"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-16-0201"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-11-610436"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.10.008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-457"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-016-2007-1"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1046\/j.1440-1827.2000.01108.x","article-title":"The world health organization classification of malignant lymphomas in japan: incidence of recently recognized entities. 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