{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:39:40Z","timestamp":1789879180401,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In myeloproliferative neoplasms (<jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>), interferon\u2010alpha (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b1) is an effective treatment with disease\u2010modifying properties but currently with no clear predictors of treatment outcome. Recent genomewide association studies in chronic hepatitis C have found a strong influence of genetic polymorphism near the <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>28B (<jats:styled-content style=\"fixed-case\">IFNL<\/jats:styled-content>3)<\/jats:italic> gene in response to <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b1 treatment. In this study, we sought to evaluate the prognostic impact of <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>28B rs12979860<\/jats:italic>,<jats:italic> rs8099917,<\/jats:italic> and <jats:italic>rs12980275<\/jats:italic> on <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b1 treatment response in myeloproliferative neoplasms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We retrospectively evaluated 100 patients with <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content> treated with <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b1. The hematologic treatment response on <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b1 was compared between patients and correlated with host genetic variations in <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>28B. The genotypes of <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>28B<\/jats:italic> were determined by allelic discrimination assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> genotype of <jats:italic>rs12979860<\/jats:italic> was found significantly associated with hematologic response in polycythemia vera (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>) with a complete response (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>) in 79% (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>) compared to 48% (non\u2010<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>), (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.036). No association between the genotypes and treatment response on hydroxyurea was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results imply an effect of <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>28B<\/jats:italic> genotype on the outcome of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b1 treatment in <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13034","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T15:54:42Z","timestamp":1516895682000},"page":"419-425","source":"Crossref","is-referenced-by-count":23,"title":["Genetic variation in <i><scp>IL<\/scp>28B<\/i> (<i><scp>IFNL<\/scp>3<\/i>) and response to interferon\u2010alpha treatment in myeloproliferative neoplasms"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9757-5243","authenticated-orcid":false,"given":"Marie","family":"Lindgren","sequence":"first","affiliation":[{"name":"Department of Medicine Kalmar County Hospital  Kalmar Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Samuelsson","sequence":"additional","affiliation":[{"name":"Department of Medicine Stockholm South Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Hematology Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5var","family":"Knutsen","sequence":"additional","affiliation":[{"name":"Department of Hematology Ullev\u00e5l University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Ghanima","sequence":"additional","affiliation":[{"name":"Department of Medicine \u00d6stfold Hospital  Fredrikstad Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Westin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L.","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Hematology and Coagulation Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Department of Medicine Section of Hematology NU Hospital  Uddevalla Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1525-1331","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Andr\u00e9asson","sequence":"additional","affiliation":[{"name":"Department of Hematology and Coagulation Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Department of Medicine Section of Hematology NU Hospital  Uddevalla Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra063728"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.8436"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1312542"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311347"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2012.0120"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-258772"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-442012"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-320069"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.12.69"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1182\/blood.V124.21.1861.1861","article-title":"A retrospective cohort study of interferon\u2010alpha therapy in myeloproliferative neoplasms; 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