{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T03:46:13Z","timestamp":1768448773910,"version":"3.49.0"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T00:00:00Z","timestamp":1528761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>Risk of thrombosis is significantly enhanced by both elevated platelet (PLT<\/jats:styled-content>) and white blood cell (WBC<\/jats:styled-content>) counts according to a retrospective analysis of a large anagrelide registry in thrombocythemic MPN<\/jats:styled-content> patients. We were interested in the impact of elevated WBC<\/jats:styled-content> counts on thrombosis risk in patients where PLT<\/jats:styled-content> counts were reduced below the calculated cutoff of 574.5\u00a0G\/L by treatment with anagrelide.<\/jats:p><\/jats:sec>Methods<\/jats:title>Cox regression analysis and Kaplan\u2010Meier plot were applied on all patients in the registry with optimized PLT<\/jats:styled-content> counts.<\/jats:p><\/jats:sec>Results<\/jats:title>Using the calculated cutoff of 9.66\u00a0G\/L for WBC<\/jats:styled-content>, Cox regression analysis revealed a clear influence of elevated WBC<\/jats:styled-content> counts on the occurrence of a major thrombotic event (P<\/jats:italic>\u00a0=\u00a0.012). A Kaplan\u2010Meier plot revealed a markedly shorter time to a major thrombotic event for patients with WBC<\/jats:styled-content> counts above the cutoff (P<\/jats:italic>\u00a0=\u00a0.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>These data suggest that additional correction of elevated WBC<\/jats:styled-content> counts is mandatory in patients with optimally managed PLT<\/jats:styled-content> counts to reduce thrombotic risk. This study is the first investigation in a prospectively observed large patient cohort which was treated homogenously allowing for evaluation of single parameters for an effect on thrombophilia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13070","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T10:40:00Z","timestamp":1522492800000},"page":"131-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Impact of white blood cells on thrombotic risk in patients with optimized platelet count in essential thrombocythemia"],"prefix":"10.1111","volume":"101","author":[{"given":"Veronika","family":"Buxhofer\u2010Ausch","sequence":"first","affiliation":[{"name":"Division of Hematology and Blood Coagulation Department of Internal Medicine I Medical University of Vienna Vienna Austria"},{"name":"Department of Internal Medicine I Ordensklinikum Linz, Elisabethinen Hospital Linz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Steurer","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Innsbruck Medical University Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Sormann","sequence":"additional","affiliation":[{"name":"Department of Hematology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst","family":"Schloegl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3 Hanusch Hospital Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Schimetta","sequence":"additional","affiliation":[{"name":"Department of Applied Systems Research and Statistics Johannes Kepler University Linz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Gisslinger","sequence":"additional","affiliation":[{"name":"Division of Hematology and Blood Coagulation Department of Internal Medicine I Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Schalling","sequence":"additional","affiliation":[{"name":"Division of Hematology and Blood Coagulation Department of Internal Medicine I Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Theresa","family":"Krauth","sequence":"additional","affiliation":[{"name":"Division of Hematology and Blood Coagulation Department of Internal Medicine I Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Thiele","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Ruckser","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 2 Donauspital Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnther","family":"Gastl","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Innsbruck Medical University Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0295-7629","authenticated-orcid":false,"given":"Heinz","family":"Gisslinger","sequence":"additional","affiliation":[{"name":"Division of Hematology and Blood Coagulation Department of Internal Medicine I Medical University of Vienna Vienna 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