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Therapeutic considerations for advanced stage are different from those of localized\u2010stage <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>, in which radiotherapy (<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>) is generally recommended. However, the available evidence suffers from shortcomings that are relatively specific to this clinical entity due to its rarity and long survival with all available treatment modalities, including that most of the existing evidence originated at a time when diagnostic classifications, staging procedures and radiotherapeutic standards were different from those available today and when anti\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20 monoclonal antibodies were not available. Available treatment modalities include observation, systemic therapy only, <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> only and <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> in combination with systemic therapy. We review the evidence available with each of them and the data from present\u2010day clinical practice studies as well as briefly discuss what diagnostic and therapeutic developments may take place in the next few years.<\/jats:p>","DOI":"10.1111\/ejh.13093","type":"journal-article","created":{"date-parts":[[2018,5,13]],"date-time":"2018-05-13T01:19:44Z","timestamp":1526174384000},"page":"245-256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Treatment of localized\u2010stage follicular lymphoma"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0587-591X","authenticated-orcid":false,"given":"Marc","family":"Sorigue","sequence":"first","affiliation":[{"name":"Department of Hematology ICO\u2010Hospital Germans Trias i Pujol Institut de Recerca Josep Carreras Universitat Aut\u00f2noma de Barcelona  Badalona 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