{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:44:50Z","timestamp":1791888290100,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Dialysis\u2010dependent (DD<\/jats:styled-content>) multiple myeloma patients (MM<\/jats:styled-content>) have a poor prognosis and high tumour burden, thus may benefit from autologous peripheral blood stem cell transplantation (auto\u2010PBSCT<\/jats:styled-content>), however, these patients have an increased risk of toxicity.<\/jats:p><\/jats:sec>Aims<\/jats:title>To evaluate the outcomes (toxicity, PFS<\/jats:styled-content>, OS<\/jats:styled-content>) of high dose therapy followed by auto\u2010PBSCT<\/jats:styled-content> during an observational study and after propensity score matching.<\/jats:p><\/jats:sec>Patients and methods<\/jats:title>Between 2004\u20102015, 24 DD<\/jats:styled-content> patients, (aged 38\u201067\u00a0years), ISS<\/jats:styled-content> 3, treated with auto\u2010PBSCT<\/jats:styled-content>, requiring dialysis at diagnosis and auto\u2010PBSCT<\/jats:styled-content> were evaluated, matched and compared to 55 normal renal function MM<\/jats:styled-content> patients (NRF<\/jats:styled-content>) with ISS<\/jats:styled-content> 3 for outcomes of interest.<\/jats:p><\/jats:sec>Results<\/jats:title>In DD<\/jats:styled-content> patients compared to NRF<\/jats:styled-content> patients risk of mucositis (88% vs 55%), infection (79% vs 51%), parenteral nutrition (50% vs 24%), diarrhoea (71% vs 38%), prolonged duration of hospitalisation (medians: 30 vs 21\u00a0days), requirement for RBC<\/jats:styled-content> transfusion (83% vs 36%) were significantly higher, while no significant differences were found in post\u2010transplant response (ORR<\/jats:styled-content>; 75% vs 87%), 5\u2010year PFS<\/jats:styled-content> (36% vs 20%) and OS<\/jats:styled-content> (39% vs 50%). Subgroup analyses based on toxicity supported these results.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Despite the increased risk of toxicity in DD<\/jats:styled-content> patients these events do not significantly affect both the PFS<\/jats:styled-content> and OS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13101","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T16:23:50Z","timestamp":1527179030000},"page":"475-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Autologous peripheral blood stem cell transplantation in dialysis\u2010dependent multiple myeloma patients\u2014DAUTOS<\/scp> Study of the Polish Myeloma Study Group"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5626-1750","authenticated-orcid":false,"given":"Anna","family":"Waszczuk\u2010Gajda","sequence":"first","affiliation":[{"name":"Department of 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