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A few studies have suggested that the use of thrombopoietin agonists (<jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content>a) may be useful in this setting. Our retrospective study is the largest series published to date; we retrospectively evaluated <jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content>a efficacy and safety in 20 adult allo<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> recipients who received <jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content>a as a compassionate use for clinically relevant thrombocytopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve of 20 patients (60%) responded, with a 180\u2010day cumulative incidence of successful platelet recovery to \u226530 and \u226550\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L of 57% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 44%\u201071%) and 32% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 18%\u201046%), respectively, which were reached at a median of 28 and 34\u00a0days from the start of therapy. Fifty percent of the responders were able to discontinue the <jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content>a without recurrence of severe thrombocytopenia and its associated hemorrhagic complications. No serious adverse events were reported. Possible variables associated with higher response to <jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content>a were as follows: age\u00a0&lt;\u00a040\u00a0years, presence of megakaryocytes in the bone marrow aspirate, and\/or prior response to other hematopoietic growth factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study adds further enthusiasm for continued research on the use of these agents for the treatment of persistent thrombocytopenia in allo<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13132","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T07:55:55Z","timestamp":1530258955000},"page":"407-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Usefulness of thrombopoietin receptor agonists for persistent clinically relevant thrombocytopenia after allogeneic stem cell transplantation"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9147-3692","authenticated-orcid":false,"given":"Anna","family":"Bosch\u2010Vilaseca","sequence":"first","affiliation":[{"name":"Hematology Department Hospital de la Santa Creu i Sant Pau Biomedical Research Institute (IIB Sant\u2010Pau) and Jos\u00e9 Carreras Leukemia Research Institute Autonomous University of Barcelona (UAB)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Garc\u00eda\u2010Cadenas","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital de la Santa Creu i Sant Pau Biomedical Research Institute (IIB Sant\u2010Pau) and Jos\u00e9 Carreras Leukemia Research Institute Autonomous University of Barcelona (UAB)  Barcelona 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