{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:46:18Z","timestamp":1790142378639,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T00:00:00Z","timestamp":1535932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG EXC1003"],"award-info":[{"award-number":["DFG EXC1003"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Follicular lymphoma (<jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>) is the most frequent indolent lymphoma subtype in adults. Maintenance therapy with rituximab is frequently applied to <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> patients with complete or partial response following initial chemoimmunotherapy. However, radioimmunotherapy with <jats:sup>90<\/jats:sup>Y\u2010ibritumomab\u2010tiuxetan represents a therapeutic alternative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To compare the clinical and the prognostic impact of both therapies, a study collective of n\u00a0=\u00a056 patients diagnosed with indolent B\u2010cell lymphoma was retrospectively investigated. The study collective was subdivided into two groups: n\u00a0=\u00a036 patients treated with rituximab maintenance therapy vs n\u00a0=\u00a020 patients treated with <jats:sup>90<\/jats:sup>Y\u2010ibritumomab\u2010tiuxetan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No prognostic differences for performance status, <jats:styled-content style=\"fixed-case\">FLIPI<\/jats:styled-content> score, gender, or B\u2010symptoms were found for <jats:sup>90<\/jats:sup>Y\u2010ibritumomab\u2010tiuxetan or rituximab maintenance therapy. Overall survival rates and progression\u2010free survival did not differ between both maintenance therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our retrospective single\u2010center analysis of two patient groups without major differences in prognostic parameters revealed similar outcome with two different maintenance therapies. Hence, <jats:sup>90<\/jats:sup>Y\u2010ibritumomab\u2010tiuxetan therapy might offer a valuable alternative treatment option for <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> patients with partial response. However, large prospective trials are needed to confirm the reported findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13138","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T10:56:01Z","timestamp":1531306561000},"page":"514-521","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<sup>90<\/sup>Y\u2010ibritumomab\u2010tiuxetan as a therapeutic alternative for follicular lymphoma (<scp>FL<\/scp>): A single\u2010center experience"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2730-5704","authenticated-orcid":false,"given":"Eva U.","family":"Spukti","sequence":"first","affiliation":[{"name":"Department of Medicine A, Hematology, Oncology and Pulmonary Medicine University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Henning","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Medicine A, Hematology, Oncology and Pulmonary Medicine University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arik","family":"Schulze","sequence":"additional","affiliation":[{"name":"Department of Medicine A, Hematology, Oncology and Pulmonary Medicine University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Schliemann","sequence":"additional","affiliation":[{"name":"Department of Medicine A, Hematology, Oncology and Pulmonary Medicine University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"G\u00f6rlich","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Clinical Research Westfaelische Wilhelms\u2010Universitaet Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Wardelmann","sequence":"additional","affiliation":[{"name":"Gerhard\u2010Domagk\u2010Institute of Pathology University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Gerhard\u2010Domagk\u2010Institute of Pathology University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Lenz","sequence":"additional","affiliation":[{"name":"Department of Medicine A, Hematology, Oncology and Pulmonary Medicine University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang E.","family":"Berdel","sequence":"additional","affiliation":[{"name":"Department of Medicine A, Hematology, Oncology and Pulmonary Medicine University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Kerkhoff","sequence":"additional","affiliation":[{"name":"Department of Medicine A, Hematology, Oncology and Pulmonary Medicine University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4434"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds429"},{"key":"e_1_2_6_4_1","unstructured":"American Cancer Society.Survival rates and factors that affect prognosis (outlook) for non\u2010hodgkin lymphoma;2017."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.1495"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.1398"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-624288"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3175"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0016"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.4618"},{"key":"e_1_2_6_11_1","volume-title":"Follicular lymphoma Union for International Cancer Control, 2014 review of cancer medicines on the WHO list of essential medicines Executive summary","author":"Union for International Cancer Control","year":"2014"},{"key":"e_1_2_6_12_1","unstructured":"BuskeC DreylingM HeroldM LohriA NeumeisterP WillenbacherW.Follikul\u00e4res Lymphom;2017."},{"key":"e_1_2_6_13_1","volume-title":"NCCN clinical practice guidelines in oncology. 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