{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:47:09Z","timestamp":1762876029146,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T00:00:00Z","timestamp":1535673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to analyse the clinical characteristics and outcome of children diagnosed with Ph+ <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A total of 2591 newly diagnosed <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> children were treated in Poland between the years 2005 and 2017. Of those, 44 were diagnosed with Ph(+) <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>. The patients were treated according to protocols: <jats:styled-content style=\"fixed-case\">ALL IC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BFM<\/jats:styled-content> 2002 and 2009 (26 patients), EsPh<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> (12 patients), initially <jats:styled-content style=\"fixed-case\">ALL IC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BFM<\/jats:styled-content> and then EsPh<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> (6 patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median of follow\u2010up in the observed group was 3\u00a0years. Overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) and event\u2010free survival (<jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content>) of Ph+ <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> group were 0.73 and 0.64. <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content> of patients after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> were 0.78 and 0.66, while without <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> were 0.6 and 0.6, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.27 and 0.63. <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> was 0.8 for patients treated with chemotherapy plus imatinib and 0.61 for chemotherapy alone, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.22, while <jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content> was 0.66 (imatinib therapy) and 0. 61 (without imatinib), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.41.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study suggests that adding imatinib to intensive chemotherapy seems to improve outcome. However, this study was limited by a small number of patients and a variety of chemotherapy regimens with or without imatinib.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13142","type":"journal-article","created":{"date-parts":[[2018,7,14]],"date-time":"2018-07-14T16:42:54Z","timestamp":1531586574000},"page":"542-548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical characteristics and analysis of treatment result in children with Ph\u2010positive acute lymphoblastic leukaemia in Poland between 2005 and 2017"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7207-156X","authenticated-orcid":false,"given":"Joanna","family":"Zawitkowska","sequence":"first","affiliation":[{"name":"Department of Paediatric Haematology, Oncology and Transplantology Medical University of Lublin  Lublin 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