{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:27:08Z","timestamp":1780396028757,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In hematology and oncology, in particular in the setting of allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT), vancomycin\u2010resistant <jats:italic>Enterococcus<\/jats:italic> spp. (VRE) colonization rates are high due to previous hospital stays and preceding antibiotic treatment and colonized patients have a lower overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We reanalyzed our previously published cohort, to unravel which colonization timepoints before and during allo\u2010HSCT might be predictive for the subsequent outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>We report about 268 patients with acute myeloid leukemia receiving an allo\u2010HSCT between 2006 and 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 129 never\u2010colonized patients, 15 previously colonized patients (positive only before admission for allo\u2010HSCT), 41 persistently colonized patients (positive before and at admission for allo\u2010HSCT), and 83 newly colonized patients (positive only during allo\u2010HSCT). Persistently and newly colonized patients had a worse 60\u00a0months OS due to increased incidence of non\u2010relapse\u2010related mortality (NRM) than never\u2010colonized patients (OS: never\u2010colonized: 61.0% vs persistently colonized: 43.5%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.023 vs newly colonized: 45.6%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.046). In contrast, OS and NRM of never\u2010colonized and previously colonized patients as well as between persistently and newly colonized patients were similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients can lose their VRE colonization status and acquisition of VRE during inpatient stay for allo\u2010HSCT decreases survival to a similar extend as persistent colonization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13151","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T13:20:53Z","timestamp":1532611253000},"page":"620-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Timepoints of vancomycin\u2010resistant <i>Enterococcus<\/i> colonization predict outcomes of acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplantation"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6408-3536","authenticated-orcid":false,"given":"Sebastian","family":"Scheich","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology University Hospital Frankfurt Frankfurt am Main Germany"},{"name":"University Center for Infectious Diseases University Hospital Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology University Hospital Frankfurt Frankfurt am Main Germany"},{"name":"University Center for Infectious Diseases University Hospital Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalie","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology University Hospital Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne C.","family":"Wilke","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology University Hospital Frankfurt Frankfurt am Main Germany"},{"name":"University Center for Infectious Diseases University Hospital Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lindner","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology University Hospital Frankfurt Frankfurt am Main Germany"},{"name":"University Center for Infectious Diseases University Hospital Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Reinheimer","sequence":"additional","affiliation":[{"name":"University Center for Infectious Diseases University Hospital Frankfurt Frankfurt am Main Germany"},{"name":"Institute for Medical Microbiology and Infection Control University Hospital Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Wichelhaus","sequence":"additional","affiliation":[{"name":"University Center for Infectious Diseases University Hospital Frankfurt Frankfurt am Main Germany"},{"name":"Institute for Medical Microbiology and Infection Control University Hospital Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hogardt","sequence":"additional","affiliation":[{"name":"University Center for Infectious Diseases University Hospital Frankfurt Frankfurt am Main Germany"},{"name":"Institute for Medical Microbiology and Infection Control University Hospital Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkhard","family":"A. 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