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The aim of this paper is to review the diagnosis and the management of PNH patients, with the primary focus on identifying high\u2010risk groups. Additionally, the implementation and prognostic value of the defined high\u2010risk groups will be commented on and the management of PNH patients is discussed from a Belgian perspective. Finally, based on the available data, recommendations are provided. Eculizumab is a potent C5 complement inhibitor and reduces intravascular haemolysis and thrombosis in PNH patients and improves their quality of life. As thrombosis is the main cause of death in PNH patients, identifying high\u2010risk PNH patients in need of therapy is essential. Currently, novel complement inhibitors are in development and the first data seem promising. Another challenge in PNH is to identify new markers to assess the thrombotic risk to achieve a better risk\u2010based prophylactic anti\u2010thrombotic management. Finally, because of the low prevalence of the disease, PNH patients should be included in the prospective PNH registry, which will offer new insights on the natural course of the disease and the impact of treatment of PNH.<\/jats:p>","DOI":"10.1111\/ejh.13166","type":"journal-article","created":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T06:48:48Z","timestamp":1535784528000},"page":"737-749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Diagnosis and management of PNH: Review and recommendations from a Belgian expert panel"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6881-417X","authenticated-orcid":false,"given":"Timothy","family":"Devos","sequence":"first","affiliation":[{"name":"Department of Haematology University Hospitals Leuven Leuven Belgium"},{"name":"Laboratory of Experimental Transplantation, Department of Microbiology and Immunology KU Leuven Leuven 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