{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:53Z","timestamp":1787014133959,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Management of pregnant patients with BCR\u2010ABL\u2010positive leukemia is challenging. Managing a patient who has been diagnosed while pregnant requires a different approach as compared to a patient who plans to become pregnant while on the treatment with tyrosine kinase inhibitor (TKI). Interferon (IFN)\u2010alpha is a useful option in both situations due to teratogenic potential of TKIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We presented a series of 12 successful pregnancies in 11 women with BCR\u2010ABL\u2010positive leukemia, whose leukemia was managed with IFN\u2010alpha throughout their pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All children have normal growth and development. All patients remained at least in hematological response and could start or resume TKI after delivery or breastfeeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Because of the increased risk of teratogenicity and spontaneous abortion in female patient with pregnancy, when receiving TKI, IFN\u2010alpha can be considered a safe drug to be administered throughout pregnancy and could represent the drug of choice in this situation during the era of TKI therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.13167","type":"journal-article","created":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T10:15:57Z","timestamp":1536056157000},"page":"774-780","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Successful pregnancies in patients with BCR\u2010ABL\u2010positive leukemias treated with interferon\u2010alpha therapy during the tyrosine kinase inhibitors era"],"prefix":"10.1111","volume":"101","author":[{"given":"Marie","family":"Balsat","sequence":"first","affiliation":[{"name":"Department of Clinical Hematology, Hospices Civils de Lyon Lyon\u2010Sud Hospital Pierre B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Etienne","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Research Unit, Hospices Civils de Lyon Lyon\u2010Sud Hospital  Pierre B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Elhamri","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Research Unit, Hospices Civils de Lyon Lyon\u2010Sud Hospital  Pierre B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Hayette","sequence":"additional","affiliation":[{"name":"Laboratory of 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