{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:53Z","timestamp":1787014133140,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T00:00:00Z","timestamp":1542153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We report cases of myelodysplastic syndrome\/myeloproliferative neoplasms (MDS\/MPN) with trisomy 8 associated with inflammatory and autoimmune diseases (IADs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Data for 21 patients with trisomy 8\u2010MDS\/MPN and IADs were analyzed and compared to 103 patients with trisomy 8\u2010MDS\/MPN without IADs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age of MDS\/MPN patients with IADs was 67 [59\u201080]. The IADs were Beh\u00e7et's\u2010like disease in 11 (52%) patients, inflammatory arthritis in 4 (19%) and Sj\u00f6gren's syndrome, autoimmune hemolytic anemia, aseptic abscess, periarteritis nodosa, Sweet's syndrome and unclassified vasculitis in one patient each. Overall, 17\/21 (81%) patients with IADs received treatment (88% with steroids), with complete and partial response in 7\/17 (35%) and 8\/17 (47%), respectively. The effect of MDS treatment on IADs could be assessed in seven patients receiving azacytidine: five achieved remission and two partial response. As compared with the 103 trisomy 8\u2010MDS\/MPN cases without IADs, those with IADs were more often non\u2010European (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.005) and had poor karyotype (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). We found no difference in overall survival or acute myeloid leukemia progression between trisomy 8\u2010associated MDS\/MPN with and without IADs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The spectrum of IADs associated with trisomy 8\u2010positive MDS\/MPN is dominated by Beh\u00e7et's\u2010like disease. Steroid therapy is effective, but mostly sparing therapies are necessary. Azacytidine could be an effective alternative.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.13174","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T09:13:40Z","timestamp":1537089220000},"page":"63-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Inflammatory disorders associated with trisomy 8\u2010myelodysplastic syndromes: French retrospective case\u2010control study"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8131-9464","authenticated-orcid":false,"given":"Nadege","family":"Wesner","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Inflammation\u2010Immunopathology\u2010Biotherapy Department (DHU i2B) Assistance Publique\u2010H\u00f4pitaux de Paris, H\u00f4pital Saint\u2010Antoine Paris France"},{"name":"Sorbonne Universit\u00e9s  F-75012 Paris France"},{"name":"INSERM U938, Centre de Recherche Saint\u2010Antoine (CRSA) UMPC University Paris 06, Sorbonne Universit\u00e9s Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Drevon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Inflammation\u2010Immunopathology\u2010Biotherapy Department (DHU i2B) Assistance Publique\u2010H\u00f4pitaux de Paris, H\u00f4pital Saint\u2010Antoine Paris France"},{"name":"Sorbonne Universit\u00e9s  F-75012 Paris France"},{"name":"INSERM U938, Centre de Recherche Saint\u2010Antoine (CRSA) UMPC University Paris 06, Sorbonne Universit\u00e9s Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Guedon","sequence":"additional","affiliation":[{"name":"INSERM, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique IPLESP AP\u2010HP, H\u00f4pital Saint Antoine, Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Baptiste","family":"Fraison","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine H\u00f4pital S\u00e8te S\u00e8te France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Trad","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Assistance Publique\u2010H\u00f4pitaux de Paris, H\u00f4pital Ambroise Par\u00e9 Boulogne Billancourt France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Emmanuel","family":"Kahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine H\u00f4pital Foch Suresnes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achille","family":"Aouba","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine CH Caen Caen 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