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The study was prematurely terminated due to severe complications, and no effect of adding clarithromycin was found. The aim of this study was to compare health\u2010related quality of life (HRQoL) between the two groups and to explore the coherence hereof with adverse event (AE) registration by clinicians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients completed three validated HRQoL questionnaires at inclusion, before cyclophosphamide priming, and two months after high\u2010dose therapy (HDT). The mean score difference was interpreted by clinically relevant differences between groups. Spearman's correlation analysis was used to compare patient\u2010reported toxicities with AEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 58 included patients, 55 participated in the HRQoL reporting. Before cyclophosphamide priming, patients in the clarithromycin group reported clinically relevant reduced HRQoL for eleven domains with persistent reduction in four domains two months after HDT. Poor correlation between patient\u2010reported toxicities and clinician\u2010reported AEs was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite the premature study termination, our data demonstrate impaired HRQoL when clarithromycin was added to the VCD regimen. We found clear underreporting of toxicities by clinicians. ClinicalTrials.gov number NCT02573935.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13175","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T10:10:09Z","timestamp":1537351809000},"page":"70-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clarithromycin added to bortezomib\u2010cyclophosphamide\u2010dexamethasone impairs health\u2010related quality of life in multiple myeloma patients"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2083-3870","authenticated-orcid":false,"given":"Lene Kongsgaard","family":"Nielsen","sequence":"first","affiliation":[{"name":"Quality of Life Research Center, Department of Haematology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias Wirenfeldt","family":"Klausen","sequence":"additional","affiliation":[{"name":"Department of Haematology University Hospital of Copenhagen at Herlev Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Jarden","sequence":"additional","affiliation":[{"name":"Department of Haematology University Hospital of Copenhagen at Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Frederiksen","sequence":"additional","affiliation":[{"name":"Quality of Life Research Center, Department of Haematology Odense University Hospital Odense Denmark"},{"name":"Department of Haematology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-731X","authenticated-orcid":false,"given":"Annette Juul","family":"Vangsted","sequence":"additional","affiliation":[{"name":"Department of Haematology University Hospital of Copenhagen at Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trung","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Haematology University Hospital of Copenhagen at Herlev Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida Bruun","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Haematology Vejle Hospital Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf Christian","family":"Fr\u00f8lund","sequence":"additional","affiliation":[{"name":"Department of Haematology Zealand University Hospital Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7753-6768","authenticated-orcid":false,"given":"Christen Lykkegaard","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Haematology Zealand University Hospital Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Abildgaard","sequence":"additional","affiliation":[{"name":"Quality of Life Research Center, Department of Haematology Odense University Hospital Odense Denmark"},{"name":"Department of Haematology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Gregersen","sequence":"additional","affiliation":[{"name":"Department of Haematology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2016.03.011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-737403"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-7625.2007.00441.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1188\/14.ONF.411-419"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c2921"},{"key":"e_1_2_6_7_1","unstructured":"European Medicine Agency.The use of patient reported outcome (PRO) measures in oncology studies. 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