{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T12:32:27Z","timestamp":1750941147326,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,20]],"date-time":"2019-01-20T00:00:00Z","timestamp":1547942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The GMALL\u2010B\u2010ALL\/NHL2002 protocol is effective in Burkitt lymphoma\/leukemia (BL). Its role in other aggressive lymphomas and in patients with simultaneous central nervous system (CNS) and peripheral involvement is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective outcome analysis in 76 patients with BL (n\u00a0=\u00a026), B\u2010lymphoblastic lymphoma (B\u2010LBL; n\u00a0=\u00a03), diffuse large B\u2010cell lymphoma (DLBCL; n\u00a0=\u00a031), mantle cell lymphoma (MCL; n\u00a0=\u00a06), transformed B\u2010cell non\u2010Hodgkin lymphomas (tB\u2010NHL; n\u00a0=\u00a07), and T\u2010cell NHL (T\u2010NHL; n\u00a0=\u00a03) treated with the GMALL\u2010B\u2010ALL\/NHL2002 protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>73.1% of scheduled chemotherapy cycles were administered. Treatment was discontinued in 38 patients (50.0%) due to progression (n\u00a0=\u00a014), toxicities (n\u00a0=\u00a011), scheduled treatment change (n\u00a0=\u00a06), and unknown reasons (n\u00a0=\u00a07). All BL\/B\u2010LBL patients were treated first\u2010line, and at a median follow\u2010up of 124.7\u00a0months, median progression\u2010free survival was not reached. In DLBCL, median PFS was 68.4\u00a0months in first\u2010line treated patients and 3.7\u00a0months in relapsed\/refractory patients. CNS involvement was present in 10 non\u2010BL\/B\u2010LBL cases and did not have a negative impact on survival in first\u2010line treated patients but was fatal in all relapsed\/refractory patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study confirmed the activity of the GMALL\u2010B\u2010ALL\/NHL2002 protocol in BL\/B\u2010LBL. It was also effective in first\u2010line treated non\u2010BL\/B\u2010LBL lymphomas with and without simultaneous CNS\u2010\/peripheral involvement, but ineffective in relapsed\/refractory disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13199","type":"journal-article","created":{"date-parts":[[2018,11,24]],"date-time":"2018-11-24T16:54:11Z","timestamp":1543078451000},"page":"241-250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of the GMALL\u2010B\u2010ALL\/NHL2002 protocol in Burkitt leukemia\/lymphoma and aggressive non\u2010Hodgkin\u2010lymphomas with or without CNS involvement"],"prefix":"10.1111","volume":"102","author":[{"given":"Maria","family":"Sakarou","sequence":"first","affiliation":[{"name":"Department of Haematology, University Hospital Essen University of Duisburg\u2010Essen Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewin","family":"Eisele","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen University of Duisburg\u2010Essen Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4034-9472","authenticated-orcid":false,"given":"Ulrich","family":"D\u00fchrsen","sequence":"additional","affiliation":[{"name":"Department of Haematology, University Hospital Essen University of Duisburg\u2010Essen Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2230-3873","authenticated-orcid":false,"given":"Andreas","family":"H\u00fcttmann","sequence":"additional","affiliation":[{"name":"Department of Haematology, University Hospital Essen University of Duisburg\u2010Essen Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,20]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1056\/NEJMoa011795"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1016\/S1470-2045(06)70664-7"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1056\/NEJMoa1308392"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1093\/annonc\/mdt058"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.1007\/s00277-017-3167-7"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1056\/NEJM199304083281404"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_1","DOI":"10.1200\/JCO.2017.76.8093"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_1","DOI":"10.1182\/blood-2014-03-563627"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_1","DOI":"10.1200\/JCO.1999.17.4.1244"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_1","DOI":"10.1200\/JCO.2006.09.2403"},{"unstructured":"Common Terminology Criteria for Adverse Events (CTCAE) v4.03.U.S. Department of Health and Human Services National Institutes of Health National Cancer Institute; June 14 2010.","key":"e_1_2_6_12_1"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_1","DOI":"10.1007\/s00277-017-3151-2"},{"doi-asserted-by":"publisher","key":"e_1_2_6_14_1","DOI":"10.1111\/bjh.15170"},{"doi-asserted-by":"publisher","key":"e_1_2_6_15_1","DOI":"10.1111\/bjh.15258"},{"doi-asserted-by":"publisher","key":"e_1_2_6_16_1","DOI":"10.1007\/s00280-002-0447-1"},{"doi-asserted-by":"publisher","key":"e_1_2_6_17_1","DOI":"10.1182\/blood-2017-03-769620"},{"doi-asserted-by":"publisher","key":"e_1_2_6_18_1","DOI":"10.1200\/JCO.2010.28.1618"},{"doi-asserted-by":"publisher","key":"e_1_2_6_19_1","DOI":"10.1200\/JCO.2013.53.9593"},{"doi-asserted-by":"publisher","key":"e_1_2_6_20_1","DOI":"10.1200\/JCO.2008.16.8021"},{"doi-asserted-by":"publisher","key":"e_1_2_6_21_1","DOI":"10.3324\/haematol.2012.077917"},{"doi-asserted-by":"publisher","key":"e_1_2_6_22_1","DOI":"10.1182\/blood-2003-02-0542"},{"doi-asserted-by":"publisher","key":"e_1_2_6_23_1","DOI":"10.1200\/JCO.2015.61.1236"},{"doi-asserted-by":"publisher","key":"e_1_2_6_24_1","DOI":"10.1016\/j.ejca.2018.01.073"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.13199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.13199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejh.13199","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.13199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T11:57:25Z","timestamp":1694692645000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.13199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,20]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/ejh.13199"],"URL":"https:\/\/doi.org\/10.1111\/ejh.13199","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"type":"print","value":"0902-4441"},{"type":"electronic","value":"1600-0609"}],"subject":[],"published":{"date-parts":[[2019,1,20]]},"assertion":[{"value":"2018-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}