{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:03:40Z","timestamp":1747184620326,"version":"3.40.5"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Characteristics and risk factors (RFs) of invasive fungal disease (IFD) have been little studied in the setting of umbilical cord blood transplantation (UCBT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We retrospectively included 205 single\u2010unit myeloablative UCBT recipients with a median follow\u2010up of 64\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010six episodes of IFD were observed in 48 patients (23%) at a median time of 123\u00a0days after stem cell infusion. Invasive mold disease (IMD) occurred in 42 cases, 38 of them (90%) caused by invasive aspergillosis whereas invasive yeast disease (IYD) occurred in 14 cases, most of them due to candidemia (n\u00a0=\u00a012, 86%). The 5\u2010year cumulative incidence of IFD, IMDs, and IYDs was 24% 19%, and 7%, respectively. In multivariate analysis, three RFs for IMDs were identified: age &gt;30\u00a0years (HR 3.5, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.017), acute grade II\u2010IV graft\u2010versus\u2010host disease (HR 2.3, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.011), and \u22651 previous transplant (HR 3.1, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.012). The probability of IMDs was 2.5%, 14%, and 33% for recipients with none, 1, or 2\u20103 RFs, respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Among IFD, IMDs had a negative effect on non\u2010relapse mortality in multivariate analysis (HR 1.6, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.039). IMDs showed a negative impact\u00a0on overall\u00a0survival (HR 1.59, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.018).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Invasive mold disease were very common and serious complication after UCBT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13202","type":"journal-article","created":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T12:49:02Z","timestamp":1543668542000},"page":"331-340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Invasive fungal disease in patients undergoing umbilical cord blood transplantation after myeloablative conditioning regimen"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0024-8068","authenticated-orcid":false,"given":"Juan","family":"Montoro","sequence":"first","affiliation":[{"name":"Department of Hematology Hospital Universitario y Polit\u00e9cnico La Fe Valencia 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